Add to MyPages

This page will be saved to Cincinnati Children's MyPages, a collection of your favorite places. You can view, organize, or delete your favorites at any time.

Page Title:

Description: (optional)

E-mail this page

(All fields required)

Recipient's e-mail address

Please enter a valid e-mail.

Your name

Please enter your name.

Your e-mail

Please enter a valid e-mail.

Share this on:

Sign into CCHMC

User Name

Password

Forgot Password

Biographies

Find another Doctor or Researcher

Catherine Dent Krawczeski

High Res

Catherine Dent Krawczeski, MD

Director, Quality Improvement & Clinical Effectiveness

Co-Director, Center for Acute Care Nephrology

Associate Professor, UC Department of Pediatrics

Phone: 513-801-1801

Fax: 513-636-3952

Email: catherine.krawczeski@cchmc.org

Show All

Specialties

Clinical Interests

Cardiac intensive care; heart failure; heart transplantation; pulmonary hypertension; single ventricle physiology

Research Interests

Acute kidney injury after cardiopulmonary bypass; urinary biomarkers of renal ischemia; intensive care outcomes; cardiopulmonary bypass mediated injury

Biography

Catherine Krawczeski, MD, focuses her research on clinical outcomes after pediatric cardiac surgery. She has a particular interest in the effects of cardiac surgery and cardiopulmonary bypass on the kidney. Dr. Krawczeski's experience as a clinical investigator has been strengthened by my collaboration with Prasad Devarajan, director of the division of Nephrology, translating biomarker technology to the bedside for early diagnosis of acute kidney injury (AKI) after cardiopulmonary bypass. Their successful discovery and validation of early AKI biomarkers, such as NGAL, has set the stage for future studies of potential therapeutic interventions. Dr. Krawczeski and Dr. Devarajan have enjoyed a very successful collaboration, which has resulted in over 15 peer-reviewed publications and in intramural and national (AHA and NIH) grant funding. Based upon this success, they have also been part of a multi-center AKI consortium, studying the incidence of AKI after CPB, the application and validation of biomarker technology to the bedside, and evaluating the long-term effects of AKI on morbidity and quality of life. Their collaboration has been further strengthened by the recent creation of the Center for Acute Care Nephrology (CACN), a joint effort by the Heart Institute and the division of Nephrology (Director Goldstein; Co-Director Krawczeski), for the purpose of concentrating and coordinating clinical care and single- and multi-center AKI translational and clinical research.

Education and Training

MD: University of Missouri, Kansas City, Missouri, 1991.

Residency: Washington University, St. Louis Children's Hospital, St. Louis, Missouri.

Fellowships: Washington University, St. Louis Children's Hospital, St. Louis, Missouri.

Certification: American Board of Pediatrics 1995, recertification 2002; American Board of Pediatrics, Sub-board of Pediatric Critical Care 2000, recertification 2007; American Board of Pediatrics, Sub-board of Pediatric Cardiology 2002.

Publications

View PubMed Publications

Parikh CR, Coca SG, Devarajan P, Shlipak MG, Thiessen-Philbrook H, Edelstein CL, Wang Z, Zappitelli M, Koyner J, Krawczeski CD, Patel UD, Swaminathan M, Passik CS, Garg AX; for the TRIBE-AKI Consortium. Post-operative biomarkers predict acute kidney injury and poor outcomes after cardiac surgery. J Am Soc Nephr. 2011.

Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim R, Koyner J, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD; for the TRIBE-AKI Consortium. Early post-operative urine and serum biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephr. 2011.

Krawczeski CD, Woo JG, Wang Y, Bennett MR, Ma Q, Devarajan P. Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. J Pediatr. 2011 Jun;158(6):1009-1015.e1

Haase M, Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, Krawczeski CD, Koyner JL, Murray J, Zappitelli M, Goldstein SL, Makris K, Ronco C, Martensson J, Marthing C-R, Venge P, Siew E, Ware LB, Ikizler A, Mertens PR. The outcome of neutrophil gelatinase-associated lipocalin (NGAL)-positive subclinical acute kidney injury: A multi-center pooled analysis of prospective studies. J Am Coll Cardio. 2011 Apr;57:1752-1761

Krawczeski CD, Vandevoorde RG, Kathman T, Bennett MR, Woo JG, Wang Y, Griffiths RE, Devarajan P. Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clin J Am Soc Nephrol. 2010 Sep;5(9):1552-7.

Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt FC, Ghanayem NS, Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C, Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL, Pizarro, C, Kanter KR, Jaggars J, Jacobs J, Krawczeski CD, Pike N, McCrindle BW, Virzi L, Gaynor JW; for the Pediatric Heart Network Investigators. Outcomes of the Norwood procedure in infants randomized to a modified Blalock-Taussig versus right ventricle-to-pulmonary artery shunt. New Engl J Med. 2010 May; 362:1980-92.

Ramesh G, Krawczeski CD, Woo JG, Wang Y, Devarajan P. Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery. Clin J Am Soc Nephr. 2010 Mar;5(3):395-401.

Nguyen MT, Dent CL, Ross GF, Harris N, Manning PB, Mitsnefes MM, Devarajan P. Urinary aprotinin as a predictor of acute kidney injury after cardiac surgery in children receiving aprotinin therapy. Ped Nephr. 2008 Aug;23(8):1317-1326.

Dent CL, Ma Q, Dastrala S, Bennett M, Mistnefes M, Barasch J, Devarajan P. Plasma NGAL predicts acute kidney injury, morbidity, and mortality after cardiac surgery: a prospective study. Critical Care Medicine. 2007 Dec 10;11(6):R127

Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain MRI abnormalities following the Norwood procedure using regional cerebral perfusion. Journal of Thoracic and Cardiovascular Surgery 2005 Dec;130:1523-30.

Grants

Biomarkers of renal injury in cardiac surgery. Co-Investigator. National Heart, Lung, and Blood Institute. Jul 2007 - Jun 2012.

Phase II/III double blind, randomized, placebo controlled, clinical trial to determine the safety and efficacy of intravenous L-citrulline versus placebo in children undergoing cardiopulmonary bypass. Primary Investigator. Askepion Pharmaceuticals. Feb 2008 - Dec 2012.

Progression of acute kidney injury to chronic kidney disease. Co-Investigator. National Institutes of Health. Jan 2009 - Dec 2013.

Outcomes after single ventricle reconstruction in children with hypoplastic left heart syndrome and other single right ventricle anomalies. Primary Investigator. National Institutes of Health. Jun 2008 - Dec 2015.

Related Professionals

Doctors & Researchers

© 1999-2011 Cincinnati Children's Hospital Medical Center

3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY:1-513-636-4900