Molecular mechanisms underlying regulation and dysregulation of inflammatory responses in infectious, allergic, genetic and metabolic disease, with a focus on diseases of children.

BA: Brandeis University, Waltham, MA, 1978.

MD: University of North Carolina School of Medicine, Chapel Hill, NC, 1986.

Internal Medicine: Rhode Island Hospital, Brown University, 1986-1987.

Internal Medicine: Georgetown University Hospital, Georgetown University, 1987-1989.

NRSA Fellow: Laboratory of Parasitic Diseases, NIAID, 1989-1992.

Fellow in Infectious Diseases: Johns Hopkins University School of Medicine, 1992-1993.

Diplomate of the National Board of Medical Examiners, 1987; Diplomate in Internal Medicine, American Board of Internal Medicine, 1989; Diplomate in Infectious Disease, American Board of Internal Medicine, 1994; Certificate of Knowledge in Tropical Medicine and Travelers' Health, ASTMH, 1995

Allen JL, Trompette A, Karp CL. Toll-like receptors. In Inflammation and Allergy Drug Design, Holgate S, Wills-Karp M, Izuhara K (Eds.). Oxford:  Wiley-Blackwell, Medicine, 2011.

Divanovic S, Sawtell NM, Trompette A, Warning JI, Dias A, Cooper AM, Yap GS, Arditi M, Shimada K, DuHadaway JB, Prendergast GC, Basaraba RJ, Mellor AL, Munn DH, Aliberti J, Karp CL. Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis. 2011. In press.

Divanovic S, Trompette A, Ashworth JI, Rao MB, Karp CL. Therapeutic enhancement of protective immunity during experimental Leishmania major infection. PLoS Neglected Tropical Diseases. 2011. 5(9): e1316. doi:10.1371/journal.pntd.0001316

Karp CL, Mahanty S. Approach to the patient with HIV and coinfecting tropical infectious diseases. in Tropical Infectious Diseases: Principles, Pathogens, and Practice, 3RD Edition; ed. Guerrant RL, Walker DH, and Weller PF. Elsevier Churchill Livingstone, Philadelphia. 2011. 1046-1065.

Puntambekar SS, Bergmann CC, Savarin C, Karp CL, Phares TW, Parra GI, Hinton DR, Stohlman SA. Shifting hierarchies of IL-10 producing T cell populations in the CNS during acute and persistent viral encephalomyelitis. J Virol. 2011. 85:6702-13. Epub 2011 Apr 27.PMID: 21525347.

Denning TL, Norris BA, Greene B, Madan R, Karp CL, Pulendran B. Functional specializations of intestinal dendritic cell and macrophage subsets that control TH-17 and T regulatory responses is dependent on the T:APC ratio, source of mouse strain and regional localization. J Immunol. 2011. 187:733-47. PMID: 21666057.

Karp CL. Guilt by intimate association: What makes an allergen an allergen? J Allergy Clin Immunol. 2010. 125:955-60. PMCID: PMC2868504.

Karp CL. Links between innate and adaptive immunity. In Fundamentals of Inflammation; ed. Serhan CN, Ward P, Gilroy D. 2009. Cambridge University Press, New York, NY. 2010. 28-38.

Wills-Karp M, Nathan A, Page K, Karp CL. New insights into the molecular mechanisms underlying allergenicity. Mucosal Immunology. 2010. 3:104-10. PMCID: PMC2821449.

Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, Madan R, Thorne PS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature. 2009. 457:585-588. Advanced Online Publication 12/7/08. 10.1038/nature07548. PMCID: 2843411.

Sun J, Madan R, Karp CL, Braciale TJ. Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nature Medicine. 2009. 15:277-84. Advanced Online Publication 2/22/09. 10.1038/nm.1929. PMCID:2693210.

Gu YY, Harley ITW, Henderson LB, Aronow BJ, Vietor I, Huber LA, Harley JB, Kilpatrick JR, Langefeld CD, Williams AH, Jegga AG, Chen J, Wills-Karp M, Arshad SH, Ewart SL, Thio CL, Flick LM, Filippi MD, Grimes HL, Drumm ML, Cutting GR, Knowles MR, Karp CL. Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature. 2009. 458:1039-1042. Advanced Online Publication 2/25/09. 10.1038/nature07811. PMCID: 2841516.

Madan R, Demircik F, Divanovic S, Trompette A, Allen J, Gu Y, Khoudon M, Hildeman D, Boespflug N, Fogolin MB, Lothar Gröbe, Greweling M, Finkelman F, Cardin R, Mohrs M, Muller W, Roers A, Waisman A, Karp CL. Non-Redundant Counter-Regulatory Roles for B Cell-Derived IL-10. J Immunology. 2009. 183:2312-20. PMCID: PMC2772089.

Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, Kuchroo VK. Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells. J Immunology. 2009. 183:797-801. PMCID: 2768608.

Murai M, Turovskaya O, Kim G, Madan R, Karp CL, Cheroutre H, Kronenberg M. IL-10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nature Immunology. 2009. 10:1178-84. PMCID: PMC2898179.

Perona-Wright G, Mohrs K, Szaba FM, Kummer LW, Madan R, Karp CL, Johnson LL, Smiley ST, Mohrs M. Systemic but not local infections elicit immunosuppressive IL-10 by natural killer cells. Cell Host Microbe. 2009. 6: 503-512. PMCID: PMC2796259.

Tschöp MH, Hugenholtz P, and Karp CL. To the core of the gut microbiome. Nature Biotechnology. 2009. 27:344-346.

Auwaerter PG, Karp CL. Coinfection with HIV and tropical infectious diseases I: Protozoal pathogens. Clin Infect Dis. 2007. 45:1208-14.

Auwaerter PG, Karp CL. Coinfection with HIV and tropical infectious diseases II: Helminthic, fungal, bacterial and viral pathogens. Clin Infect Dis. 2007. 45: 1214-20.

Divanovic S, Trompette A, Atabani SF, Madan R, Reckling S, Golenbock DT, Visintin A, Finberg RW, Tarakhovsky A, Vogel SN, Belkaid Y, Kurt-Jones EA, Karp CL. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nature Immunol 2005 ; 6:571-8. PMCID: PMC2144914.

Wills-Karp M, Santeliz J, Karp CL. The germless theory of allergic disease: the hygiene hypothesis revisited. Nature Res Immunol 2001; 1:69-75.

Karp CL, Grupe A, Schadt E, Ewart SL, Keane-Moore M, Cuomo PJ, Köhl J, Wahl L, Kuperman D, Germer S, Aud D, Peltz G, Wills-Karp M. Identification of C5 as a susceptibility locus for experimental allergic asthma. Nature Immunol 2000; 1:221-226.

Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, DD Donaldson. Interleukin-13: Central mediator of allergic asthma. Science. 1998;282:2258-2261.

Karp CL, Wysocka M, Wahl LM, Cuomo PJ, B. Sherry, Ahearn JA, Trinchieri G, Griffin DE. Mechanism of suppression of cell-mediated immunity by measles virus. Science 1996;273:228-231.

Karp CL, El-Safi SH, Wynn TA, Satti MMH, Kordofani AM, Hashim FA, Hag-Ali M, Neva FA, Nutman TB, Sacks DL. In vivo cytokine profiles in patients with kala-azar: Marked elevation of both interleukin-10 and interferon-gamma. J Clin Invest 1993;91:1644-1648. PMCID: PMC288142