Diabetes mellitus: intensive insulin management and pathophysiology of diabetes complications; obesity prevention and treatment; disorders of growth and development, with special focus on the use of growth hormone for the treatment of short stature associated with inflammatory bowel disease; early detection of renal disease in children with diabetes mellitus; effects of diabetes mellitus on renal proteoglycan synthesis

BS: Beloit College, Beloit, WI, 1974. 

MD: Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, 1977. 

PhD: University of Minnesota, 1985. 

Residency: University of Minnesota, Minneapolis, MN, 1980. 

Fellowship: University of Minnesota, Minneapolis, MN, 1984.

Certification: Pediatrics, 1982; Pediatric Endocrinology,1997; recertified 2004.

Denson LA, Kim MO, Bezold R, Carey R, Osuntokun B, Nylund C, Willson T, Bonkowski E, Li D, Ballard E, Collins M, Moyer MS, Klein DJ. A randomized controlled trial of growth hormone in active pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):130-9.

Klein DJ, Cottingham EM, Sorter M, Barton BA, Morrison JA. A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents. Am J Psychiatry. 2006 Dec;163(12):2072-9.

Morrison JA, Friedman LA, Harlan WR, Harlan LC, Barton BA, Schreiber GB, Klein DJ. Development of the metabolic syndrome in black and white adolescent girls: a longitudinal assessment. Pediatrics. 2005 Nov;116(5):1178-82.

Klein DJ, Aronson Friedman L, Harlan WR, Barton BA, Schreiber GB, Cohen RM, Harlan LC, Morrison JA. Obesity and the development of insulin resistance and impaired fasting glucose in black and white adolescent girls: a longitudinal study. Diabetes Care. 2004 Feb;27(2):378-83.

Klein DJ, Cohen RM, Rymaszewski. Proteoglycan synthesis by bovine myocardial endothelial cells is increased by long-term exposure to high concentrations of glucose. J Cell Physiol. 1995 Dec;165(3):493-502.

Brar AK, Frank GR, Richards RG, Meyer AJ, Kessler CA, Cedars MI, Klein DJ, Handwerger S. Proteoglycan synthesis by bovine myocardial endothelial cells is increased by long-term exposure to high concentrations of glucose. J Cell Physiol. 1995 Apr;163(1):30-7.

Smith EP, Lu L, Chernausek SD, Klein DJ. Insulin-like growth factor-binding protein-3 (IGFBP-3) concentration in rat Sertoli cell-conditioned medium is regulated by a pathway involving association of IGFBP-3 with cell surface proteoglycans. Endocrinology. 1994 Jul;135(1):359-64.