Clinical Interests

Complement biology; toll-like receptors; IgG Fc receptors

Research Interests

Mechanisms underlying the cross-talk between receptors for complement cleavage products C3a and C5a, IgG Fc receptors, and toll-like receptors

MD University of Mainz. Germany, 1988.

Residency Medical School Hannover, Hannover, Germany.

Certification Medical Microbiology, 1994.

Fellow in Medicine (Pulmonology) Medical School Hannover, Hannover, Germany, 1991-92.

Research Fellow in Medical Microbiology Medical School Hannover, Hannover, Germany, 1988-81.

Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, König P, Gerard NP, Gerard C, Wills-Karp M, Köhl J. A critical role for C5L2 in the pathogenesis of experimental allergic asthma. J Immunol. 2010 Dec 1;185(11):6741-52.

Zhang X, Köhl J. A complex role for complement in allergic asthma. Expert Rev Clin Immunol. 2010 Mar;6(2):269-77. Review.

Weaver DJ Jr, Reis ES, Pandey MK, Köhl G, Harris N, Gerard C, Köhl J. C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. Eur J Immunol. 2010 Mar;40(3):710-21.

Zhang X, Lewkowich IP, Köhl G, Clark JR, Wills-Karp M, Köhl J. A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells. J Immunol. 2009 Apr 15;182(8):5123-30.

Khodoun M, Strait R, Orekov T, Hogan S, Karasuyama H, Herbert DR, Köhl J, Finkelman FD. Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol. 2009 Feb;123(2):342-51.

Lewis AG, Köhl G, Ma Q, Devarajan P, Köhl J. Pharmacological targeting of C5a receptors during organ preservation improves kidney graft survival. Clin Exp Immunol. 2008 Jul;153(1):117-26.

Köhl J, Wills-Karp M. A dual role for complement in allergic asthma. Curr Opin Pharmacol. 2007 Jun;7(3):283-9.

Köhl J. Drug evaluation: the C5a receptor antagonist PMX-53. Curr Opin Mol Ther. 2006 Dec;8(6):529-38. Review.

Köhl J. Self, non-self, and danger: a complementary view. Adv Exp Med Biol. 2006;586:71-94. Review.

Köhl J, Wills-Karp M. Complement regulates inhalation tolerance at the dendritic cell/T cell interface. Mol Immunol. 2007 Jan;44(1-3):44-56.