Raphael Kopan, PhD

Director, Division of Developmental Biology

Professor, UC Department of Pediatrics

Phone: 513-636-1299

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Notch signaling; kidney organogenesis; skin organogenesis; TSLP signaling in cancer


Raphael Kopan, PhD, who is a professor of developmental biology at Cincinnati Children's Hospital Medical Center, has carried out seminal work in the field of Notch biology. This work has, and continues to have, an enormous impact on our understanding of normal tissue development and renewal, Alzheimer's disease and cancer-related research. In deciphering the mode of Notch activation and demonstrating the use of inhibitors to modulate Notch activity, Dr. Kopan's work laid the groundwork for the therapeutic use of γ-secretase inhibitors in the treatment of cancers, currently in clinical trials. His current interests in organogenesis are focused on two modular organs - skin and kidney - in which his group is trying to understand how interplay among the same seven pathways results in activation of distant programs. Dr. Kopan's work has resulted in 120 scientific articles as of 2013. He is the co-inventor of one patent, and he has served on scientific advisory boards as well as being a consultant to the pharmaceutical industry.

Education and Training

BS, MsC: Department of Zoology, Tel-Aviv University, Israel.

PhD: Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL.

Post-doctoral training: The Fred Hutchinson Cancer Research Center, Seattle, WA.


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