Rohit Kohli, MBBS, MS

Associate Medical Director, Liver Transplant Program

Co-Director, Steatohepatitis Center

Attending Physician, Liver Care Center

Associate Professor, UC Department of Pediatrics

Phone 513-803-7044

Fax 513-636-5581

Email rohit.kohli@cchmc.org

Clinical Interests

Non-alcoholic steatohepatitis; liver transplantation; mitochondrial hepatopathies

Rohit Kohli, MBBS, MS, is currently an associate professor of pediatrics at the University of Cincinnati College of Medicine and the co-director of the Cincinnati Children's Steatohepatitis Center.

Dr. Kohli received his medical degree from the Armed Forces Medical College, India in 1999 and his MS in Clinical Investigation from Northwestern University in 2006. While at Northwestern he first spent three years as a Pediatric Gastroenterology and Hepatology fellow and then subsequently as a Transplant Hepatology trainee before relocating to the University of Cincinnati in 2007.

His research work has focused on the pathogenesis of obesity related fatty liver disease (NAFLD). In particular, he has focused upon the role of reactive oxygen stress in the generation and regulation of the extreme stage of this disease; nonalcoholic steatohepatitis (NASH). Dr. Kohli's laboratory currently focuses on the role of fructose in triggering above mentioned oxidative injury and fibrosis within the liver. He also works with Drs. Randy Seeley and Stephen Woods at the Metabolic Diseases Institute at the University of Cincinnati to understand the mechanism and impact of bariatric surgical procedures on NASH and other co-morbidities of obesity.

He has published many peer-reviewed articles including articles in The Journal of Biological Chemistry, Hepatology, Journal of Pediatrics, and The American Journal of Physiology. He is the author of many book chapters and review articles. He also is the recipient of the 2007 George Ferry Young Investigator Award from the Children's Digestive Health and Nutrition Foundation and a Fellowship award from the American Association for the Study of Liver Diseases. His clinical efforts are focused within the Steatohepatitis Center and Liver Care Center in the Division of Gastroenterology, Hepatology and Nutrition at Cincinnati Children's Hospital Medical Center.
MS: Clinical Investigation, School of Public Health, Northwestern University, IL, 2004-2006.

MBBS: Armed Forces Medical College, Pune University, India,1993-1999.

Residency: Metropolitan Hospital, New York Medical College, NY, 2000-2003.

Fellowship: Gastroenterology, Children's Memorial Hospital, Northwestern University, IL, 2003-2006.

Fellowship: Transplant Hepatology, Children's Memorial Hospital, Northwestern University, IL, 2006-2007.

Certification: Pediatrics, 2004; Transplant Hepatology, 2010; Gastroenterology, 2009.

Carter-Kent C, Brunt EM, Yerian LM, Alkhouri N, Angulo P, Kohli R, Ling SC, Xanthakos SA, Whitington PF, Charatcharoenwitthaya P, Yap J, Lopez R, McCullough AJ, Feldstein AE. Relations of Steatosis Type, Grade, and Zonality to Histological Features in Pediatric Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr. 2011 Feb;52(2):190-197.

Kohli R. Indian Childhood Cirrhosis- Revisited. J of Pediatr. 2010 Nov;157:766.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44.

Kohli R, Kirby M, Setchell KD, Jha P, Klustaitis K, Woollett LA, Pfluger PT, Balistreri WF, Tso P, Jandacek RJ, Woods SC, Heubi JE, Tschoep MH, D'Alessio DA, Shroyer NF, Seeley RJ. Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G652-60.

Kohli R, Boyd T, Lake K, Dietrich K, Nicholas L, Balistreri WF, Ebach D, Shashidhar H, Xanthakos SA. Rapid progression of NASH in childhood. J Pediatr Gastroenterol Nutr. 2010 Apr;50(4):453-6.

Carter-Kent C, Brunt EM, Xanthakos SA, Kohli R, Whitington PF, Angulo P, Feldstein AE. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology. 2009 Oct; 50(4):1113-20.

Kohli R, Ramsingh H, Makkad B. The anesthetic management of ocular trauma. Int Anesthesiol Clin. 2007 Summer;45(3):83-98. Review.

Kohli R, Pan X, Malladi P, Wainwright MS, Whitington PF. Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the PI 3-kinase cell survival pathway. Journal of Biological Chemistry. 2007 Jul 20;282(29):21327-36.

Sahai A, Pan X, Paul R, Malladi P, Kohli R, Whitington PF. Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline deficient medium. American Journal of Physiology. 2006 Jul; 291(1): G55-62.

Book Chapters

Kohli R, Alonso EM, Whitington PF. Liver Transplantation: The Recipient: Long-term Outcome: Pediatric Recipient. In Living Donor Organ Transplantation, Gruessner RWG, Benedetti E (Eds). New York: McGraw Hill, 2008.