Sundeep G. Keswani, MD

Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery

Fetal Surgeon, Cincinnati Fetal Center

Director, Pediatric Advanced Wound Care and Skin Services

Assistant Professor, UC Department of Surgery

Phone 513-803-2219

Gene therapy applications; bone marrow contribution to tissue repair; fetal diagnosis and treatment.

Visit the Keswani Lab.

Dr. Sundeep G. Keswani is a pediatric and fetal surgeon. He is also the director of the Pediatric Advanced Wound Care and Skin Service (PAWS), which is a state-of-the-art wound care center devoted to the care of children. Dr. Keswani is the lead principal investigator in the Cincinnati Children’s Wound Healing Research Group, which is an NIH-funded laboratory that focuses on understanding the molecular mechanisms which underlie the fetus’ ability to regeneratively heal wounds with the goal of developing novel therapeutics to achieve regenerative wound healing in postnatal tissue.

BA: University of Colorado, Boulder, CO, 1994. 

MD: Ross University School of Medicine, 2000. 

Residency: Louisiana State University Health Sciences Center, New Orleans, LA, 2000-2007. 

Fellowship: The Children's Institute for Surgical Science, The Children's Hospital of Philadelphia & The Hospital of the University of Pennsylvania, Philadelphia, PA, 2002-2004. 

Fellowship: Postdoctoral Research Fellow, The Center for Molecular Fetal Therapy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2004. 

Fellowship: Pediatric Surgery Fellowship, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, 2007-2009. 

Licensure: American Board of Surgery Certified; Missouri State Medical Licensure, active; Ohio State Medical Licensure, active.

Alice King MD, Swathi Balaji PhD, Louis D. Le MD, Emily Marsh, Timothy M. Crombleholme MD, Sundeep G. Keswani MD. Interleukin-10 Regulates Fetal Extracellular Matrix Hyaluronan Production. Journal of Pediatric Surgery. (In press).

Visscher M, King A, Nie AM, Schaffer P, Taylor T, Pruitt D, Giaccone MJ, Ashby M, Keswani S. A Quality-Improvement Collaborative Project to Reduce Pressure Ulcers in PICUs.  Pediatrics. 2013 Jun;131(6):e1950-60.

Keswani SG, Balaji S, Le LD, Leung A, Parvadia JK, Frischer J, Yamano S, Taichman N, Crombleholme TM. Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing. Wound Repair Regen. 2013 Jun 11.

King A, Balaji S, Marsh E, Le LD, Shaaban AF, Crombleholme TM, Keswani SG. Interleukin-10 regulates the fetal hyaluronan-rich extracellular matrix via a STAT3-dependent mechanism. J Surg Res. 2013 Apr 24.

Balaji S, King A, Dhamija Y, Le LD, Shaaban AF, Crombleholme TM, Keswani SG. Pseudotyped adeno-associated viral vectors for gene transfer in dermal fibroblasts: implications for wound-healing applications. J Surg Res. 2013 Apr 3.

Keswani SG, Balaji S, Le L, Leung A, Katz AB, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM. Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis. PLoS One. 2012;7(8):e43633.

Keswani SG, Balaji S, Le L, Leung A, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM. Pseudotyped adeno-associated viral vector tropism and transduction efficiencies in murine wound healing. Wound Repair Regen. 2012 Jul-Aug;20(4):592-600.

Gordon A, Kozin ED, Keswani SG, Vaikunth SS, Katz AB, Zoltick PW, Favata M, Radu AP, Soslowsky LJ, Herlyn M, Crombleholme TM. Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation. Wound Repair Regen. 2008 Jan-Feb;16(1):70-9.

Javazon EH, Keswani SG, Badillo AT, Crombleholme TM, Zoltick PW, Radu AP, Kozin ED, Beggs K, Malik AA, Flake AW. Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Wound Repair Regen. 2007 May-Jun;15(3):350-9.

Keswani SG, Katz AB, Lim FY, Zoltick P, Radu A, Alaee D, Herlyn M, Crombleholme TM. Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen. 2004 Sep-Oct;12(5):497-504.