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Biographies

Find another Doctor or Researcher

High Res

Andreas W. Loepke, MD, PhD

Staff Anesthesiologist

Associate Professor, Division of Pediatric Anesthesia

Phone: 513-636-4408

Fax: 513-636-7337

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Specialties

Clinical Interests

Neonatal anesthesia; neonatal cardiac anesthesia; neonatal brain injury related to congenital heart disease; effects of anesthetics on the developing brain

Research Interests

Neonatal brain injury and protection

Visit the Loepke Lab.

Biography

Andreas W. Loepke, M.D., Ph.D. is a physician-scientist whose professional efforts are divided between basic science research and his clinical staff position as a Pediatric Cardiac Anesthesiologist in the Department of Anesthesia at Cincinnati Children’s Hospital. His areas of expertise comprise the effects of anesthetics on the developing brain as well as the detection, prevention, and treatment of neonatal brain damage.

After graduating from medical school in his native Germany, Dr. Loepke began training in Anesthesiology, Pain Medicine, and Intensive Care in Germany, followed by an internship in General Surgery at Pennsylvania Hospital and an a residency in Anesthesiology at Thomas Jefferson University Hospital in Philadelphia, PA. Following additional training in Pediatric Anesthesia and Pediatric Cardiac Anesthesia at the Children’s Hospital of Philadelphia, he accepted a position as staff anesthesiologist at the Children’s Hospital of Philadelphia and as an Assistant Professor of Anesthesia at the University of Pennsylvania School of Medicine.

Dr. Loepke directs a research laboratory in the Cincinnati Children’s Hospital Research Foundation and chairs the Department of Anesthesia’s Data Safety Monitoring Board. Dr. Loepke is a frequent lecturer on the effects of anesthetics on the developing brain and has received several prominent awards for his research.

Education and Training

MD: University of Dusseldorf, Germany, 1993.

PhD: University of Dusseldorf, Germany, 1995.

Residency: Thomas Jefferson Medical College, Philadelphia, PA, 1999.

Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA, 2000.

Certification: Anesthesiology, 2000.

Maintenance of Certification: Anesthesiology 2010.

Publications

View PubMed Publications

Istaphanous GK, Howard J, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer SC, Loepke AW. Comparison of the Neuroapoptotic Properties of Equipotent Anesthetic Concentrations of Desflurane, Isoflurane, or Sevoflurane in Neonatal Mice. Anesthesiology. 2011 Feb 2

Boat AC, Sadhasivam S, Loepke AW, Kurth CD. Outcome for the extremely premature neonate: how far do we push the edge?Paediatr Anaesth. 2011 Jan 10.

Murphy BL, Pun RY, Yin H, Faulkner CR, Loepke AW, Danzer SC. Heterogeneous integration of adult-generated granule cells into the epileptic brain. J Neurosci. 2011 Jan 5;31(1):105-17.

Istaphanous GK, Ward CG, Loepke AW. The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns. Best Pract Res Clin Anaesthesiol. 2010 Sep;24(3):433-49. Review.

Loepke AW. Developmental neurotoxicity of sedatives and anesthetics: a concern for neonatal and pediatric critical care medicine?Pediatr Crit Care Med. 2010 Mar;1 1(2):217-26. Review.

McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm.Anesthesiology. 2009 Sep;111(3):533-46.

Istaphanous GK, Loepke AW. General anesthetics and the developing brain. Curr Opin Anaesthesiol. 2009 Jun;22(3):368-73. Review.

Kurth CD, McCann JC, Wu J, Miles L, Loepke AW. Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets. Anesth Analg. 2009 Apr;108(4):1268-77.

Danzer SC, He X, Loepke AW, McNamara JO. Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy. Hippocampus. 2010 Jan;20(1):113-24.

Loepke AW, Istaphanous GK, McAuliffe JJ 3rd, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory.Anesth Analg. 2009 Jan;108(1):90-104.