Clinical Interests

Galactosemia; PKU; inborn errors; newborn screening; lysosomal storage disease

Research Interests

Focus on inborn errors of metabolism, with an emphasis on long term outcome in PKU and in the molecular biology of galactosemia

MD: Washington University, St. Louis, MO, 1975 to 1979. 

Internship and Residency: University of Cincinnati College of Medicine, Cincinnati, OH.

Fellowship: Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center,OH, 1982 to 1985; Clinical Genetics and Clinical Biochemical Genetics, Cincinnati Children's Hospital Medical Center, OH, 1993 to 1995.

Certification: American Board of Pediatrics, 1986; American Board of Pediatrics, Sub-Board of Pediatric Endocrinology, 1989; American Board of Medical Genetics, Board-Certified in Clinical Genetics and Clinical Biochemical Genetics, 1996, Active in MOC.

Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates.Pediatrics. 2010 Nov;126(5):910-6.

Dalal P, Leslie ND, Lindor NM, Gilbert DL, Espay AJ. Motor tics, stereotypies, and self-flagellation in primrose syndrome.Neurology. 2010 Jul 20;75(3):284-6.

Gilbert DL, Leslie EJ, Keddache M, Leslie ND. A novel hereditary spastic paraplegia with dystonia linked to chromosome 2q24-2q31.Mov Disord. 2009 Feb 15;24(3):364-70.

Burrow TA, Leslie ND. Review of the use of idursulfase in the treatment of mucopolysaccharidosis II.Biologics. 2008 Jun;2(2):311-20.

Burrow TA, Hopkin RJ, Leslie ND, Tinkle BT, Grabowski GA. Enzyme reconstitution/replacement therapy for lysosomal storage diseases.Curr Opin Pediatr. 2007 Dec;19(6):628-35. Review.

Halperin, J., Devi,  SY, Elizure, S, Stocco, C, Shehu, A, Rebourcet, D, Unterman, TG, Leslie, ND, Le, J, Binart N, Gibori, G. Prolactin signaling through the Short form of Its Receptor Represses Forkhead Transcription Factor FOXO3 and its Target Gene GALT Causing a Severe Ovarian Defect. Molecular Endocrinology. 2008 22:513-22.

Leslie, ND.  Inborn errors and Pediatric Critical Care. In Wheeler, D. ed.  Pediatric Critical Care Medicine: Basic Science and Clinical Evidence. Springer 2007. 

Tinkle, B and Leslie, N.D. Pompe Disease. Gene Clinics.  2007.

Grabowski, GA, Hopkin, RJ, Burrow, RA, Leslie, ND, Tinkle, BT. Enzyme Reconstitution/Replacement Therapy for Lysosomal Storage Diseases. Current Opinion in Pediatrics. 2007 19:628-35.

Kishnani, PS, Corzo, D., Nicolino, M, Byrne, B, Mandel, H, Hwu, W., Leslie, N., Levine, J, Spencer, C., McDonald, M., DuMontier, J, Michael, H, Chien, Y., Hopkin, R., Vijayaraghavan, S., Bruskin, D., Barholomew, D, van der Ploeg, A., Clancy, J., Prarin, R., Morin, G, Beck, N., Delagastine, G., Jokin, M., Thurberg, B., Richards, S., Bali, D., Davison, M., Worden, MA, Chen, YT, Wraith, JE.  Recombinant Human Acid -Alpha Glucosidase:  Major Clinical Benefits in Infantile-Onset Pompe Disease.  Neurology. 2007 68(2):99-109.