Ronghua Li, PhD

Instructor, UC Department of Pediatrics

Phone 513-636-5852

Email ronghua.li@cchmc.org

Mitochondrial genetic and functional study

Ronghua Li, PhD, is a mitochondrial geneticist. Right now he is focused on generation cell-specific or tissue-specific models for mitochondrial disease to study molecular/cellular mechanisms of mitochondrial disease.

MD: Luzhou Medical College, China, 1983.

PhD: West China University of Medical Sciences, China, 1995.

Research Fellow: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2001.

Research Associate: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004.

Li R, Qiu Q, Jiang P, Xue L, Lu Y, Song Y, Han J, Lu Z, Zhi S, Mo JQ, Guan MX. Mitochondrial tRNA  Mutations are Associated with Maternally Inherited Hypertension in two Han Chinese Pedigrees.  Hum Mutat. 2012;33(8):1285-93.

Wang S, Li R, Fettermann A, Li Z, Liu Y, Wang X, Zhou A, Yang L, Taschner A, Rossmanith W, Guan MX. Maternally inherited essential hypertension is associated with the novel 4263A>G mutation in the mitochondrial tRNAIle gene in a large Han Chinese family. Circulation Res. 2011;108(7):862-70.

Yan N, Cai S,Guo B, Yi M, Zhu J, Chen J, Zhang T, Li R* and Liu X*. A novel mitochondrial tRNA(Val) T1658C mutation identified in a CPEO family. Mol Vision. 2010;16:1736-42. (*Co-correspondence author)

Li R, Guan MX. Human mitochondrial leucyl-tRNA synthetase corrected mitochondrial dysfunctions due to the MELAS and diabetes associated tRNALeu(UUR) A3243G mutation. Mol Cell Biol. 2010;30; 9: 2147-54.

Li R, Tang X, Zheng J, Cai Q, Zhang T, Gong S, Zheng W, He X, Zhu Y, Xue L, Yang A, Yang L, Lu J, Guan MX. Maternally inherited hearing loss is associated with the novel mitochondrial tRNA Ser(UCN) 7505T>C mutation in a Han Chinese family. Mol Genet Metab. 2010;100;1:57-64.

Li R, Liu Y, Li Z, Yang L, Wang S, Guan MX. Failures in mitochondrial tRNAMet and tRNAGln metabolism caused by the novel 4401A>G mutation are involved in essential hypertension in a Han Chinese Family. Hypertension. 2009;54;2:329-37.

Li R, Liu Y, Li Z, Wang XJ, Yang L, Wang S, Guan MX. Mitochondrial transfer RNAMet 4435A>G mutation is associated with maternally inherited hypertension in a Chinese pedigree. Hypertension. 2009;53;6:1083-90.