Timothy D. LeCras, PhD

Associate Director of Admissions, Medical Scientist Training Program

Associate Professor, UC Department of Pediatrics

Phone 513-636-8151

Fax 513-636-7868

Email tim.lecras@cchmc.org

Lung development; bronchopulmonary dysplasia; pulmonary hypertension; asthma; pulmonary fibrosis

Timothy LeCras, PhD, investigates the causes of chronic lung diseases, including pulmonary hypertension, bronchopulmonary dysplasia, pulmonary fibrosis, and asthma. The goal of his laboratory is to use this knowledge to identify therapeutic targets and preventative measures. Our efforts are aided by very productive collaborations with other groups at Cincinnati Children's as well as other groups in the U.S.

Postdoctoral fellow: University of Virginia, Charlottesville, VA, 1993-1996.

PhD: University of Cambridge, UK, 1988-1992.

BSc: Biochemistry, Brunel University, London, UK, 1983-1987.

Acciani TH, Brandt EB, Khurana Hershey GK, Le Cras TD. (2013) Diesel Exhaust Particle Exposure Exacerbates Allergic Asthma in Young Mice.Clin Exp Allergy. 2013 Dec;43(12):1406-18. *Selected for Editors Choice in December issue 2013 Clin Exp Allergy.

Mushaben EM, Brandt EB, Hershey GKK, Le Cras TD. Differential Effects of Rapamycin and Dexamethasone in Mouse Models of Established Allergic Asthma.PLoS ONE. 2013;8(1):e54426.

Mushaben EM, Khurana Hershey GK, Pauciulo MW, Nichols WC, Le Cras TD. Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph ans wild-type mice.PLoS ONE. 2012:7(3):e32468.

Kramer EL, Hardie WD, Mushaben E, Acciani T, Pastura P, Korfhagen T, Khurana Hershey G, Whitsett JA, Le Cras TD. (2011) Rapamycin Decreases Airway Remodeling and Hyperreactivity in a Transgenic Model of Noninflammatory Lung Disease.J Appl Physiol. 2011 Dec;111:1760-7.

Mushaben EM, Kramer EL, Brandt EB, Khurana Hershey G, Le Cras TD. Rapamycin Attenuates Airway Hyperreactivity, IgE, T cells and Mediators of Allergic Asthma.J Immunol. 2011 Dec 1;187(11):5756-63.

Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson A, Holtzman MJ, Whitsett JA, Khurana Hershey GK. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic allergic asthma.Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L414-21.

Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K prevents transforming growth factor-alpha induced pulmonary fibrosis.Am J Path. 2010 Feb;176(2):679-86.

Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses Epidermal Growth Factor Receptor-mediated airway hyperresponsiveness and lung remodeling in mice.Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.

Kramer EL, Deutsch GH, Sartor M, Ikegami M, Hardie WD, Korfhagen TR, Le Cras TD. Perinatal induction of TGF-{alpha} disrupts the saccular phase of lung morphogenesis and causes remodeling: Microarray analysis.Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L314-27.

Le Cras TD, Hardie WD, Deutsch GH, Albertine KH, Ikegami M, Whitsett JA, Korfhagen TR. Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood.Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L718-729. *Published along with an editorial: D. Massaro and G. DeCarlo Massaro. (2004) Critical period for alveologenesis and early determinants of adult pulmonary disease. Am J Physiol Lung Cell Mol Physiol . 287: L715-L717.