Xia Li, PhD

Assistant Director, Cytogenetics Laboratory

Assistant Professor, UC Department of Pediatrics

Phone 513-803-4474

Email xia.li@cchmc.org

Molecular oncology

In 2010, as a principal investigator, Dr. Li received a NIH grant (2010-2015) titled “Comparative Genetics of Sweet Taste in Carnivora” (R01DC010842-01A1). Now, she serves as a consultant. She also owns two patents: 

  • 2008 Li X, Li W, Reed DR, Bachmanov AA, Brand JG. A novel taste receptor of the T1R family from domestic  cat, Felis catus (US Patent No. 10/591,360, Australia Patent No. 2004256023, European Patent Appl. 04752212.3)
  • 2009 Li X, Li W, Brand JG. Taste Receptors of the T1R Family from Domestic Dog (US Patent Application No. 11/578,472). 

As an assistant professor / assistant director of the Cytogenetics Laboratory, Dr. Li oversees the operation of the Cytogenetics Lab. In the last three years, she has signed out more than 20,000 clinical cytogenetic cases with more than 35,000 tests (80% BM and solid tumors, 20% prenatal and constitutional cases). Now her focus is to develop and implement new tests and expand test menu for FISH.

From 2010-2012, she received the following board certification/license: 

  • ABMG: Clinical Cytogenetics, 09/01/2011 
  • ASCP/BOC: Technologist in Cytogenetics, 03/19/2010
  • CAP: Team member training, 11/11/2011, Team Leader training, 12/01/2011
  • New York State of Department of Health: Cytogenetics, CQ code: LIXXX5, 04/06/2012
  • National Provider Identifier (NPI) number: 1134486848

PhD: Fudan University, Shanghai, China, 1998.

Clinical Cytogenetics Training: Children’s Hospital of Philadelphia, Philadelphia, PA, 2010.

Jiang P, Josuea J, Li X, Glaser D, Li W, Brand JG, Margolskee RF, Reed DR, Beauchamp GK. Major Taste Loss in Carnivorous Mammals. PNAS. 2012.

Li X, Bachmanov AA, Maehashi K, Li W, Lim R, Brand JG, Beauchamp GK, Reed DR, Chloe Thai, Floriano WB. Sweet receptor gene variation and aspartame taste in primates and other species. Chemical Senses. 2011.

Conlin LK, Kramer W, Hutchinson A, Li X, Riethmann H, Hakonarson H, Hosain S, Spinner NB. Genetic architecture of chromosome Ring 20 syndrome. J Med Genet. 2011;48:1-9.

Li X, Glaser D, Li W, Beauchamp GK, Brand JG. Sweet receptor gene (Tas1r2) structure and preference for sweet stimuli in species of Carnivora. J of Heredity. 2009.

McDaniel AH, Li X, Tordoff MG, Bachmanov AA, Reed DR. A locus on mouse chromosome 9 (Adip5) affects the relative size of the gonadal but not retroperitoneal adipose depot. Mammalian Genome. 2006;17:1078-1092.

Li X, Li W, Wang H, Bayley DL, Cao J, Reed DR, Bachmanov AA, Huang L, Legrand-Defretin V, Beauchamp GK, Brand JG. Cats lack a sweet taste receptor. J of Nutrition. 2006 Jul;136(7S):1932S-1934S.

Li X, Li W, Wang H, Cao J, Maehashi K, Huang L, Bachmanov AA, Reed DR, Legrand-Defretin V, Beauchamp GK, Brand JG. Pseudogenization of a sweet receptor gene accounts for cats’ indifference toward sugar. PLoS Genetics. 2005;1:e3. 

Li X, Bachmanov AA, Li S, Chen Z, Tordoff MG, Beauchamp GK, de Jong PJ, Wu C, Chen L, West DB, Ross DA, Ohmen JD, Reed DR. Genetic, physical and comparative map of the subtelomeric region of mouse chromosome 4. Mammalian Genome. 2002;13:5-19.

Li X, Inoue M, Reed DR, Huque T, Puchalski RB, Tordoff MG, Ninomiya Y, Beauchamp GK, Bachmanov AA. High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene to mouse distal chromosome 4. Mammalian Genome. 2001;12:13-16.

Bachmanov AA, Li X, Li S, Neira M, Beauchamp GK, Azen EA. High-resolution genetic mapping of the sucrose octaacetate taste aversion (Soa) locus on mouse chromosome 6. Mammalian Genome. 2001;12,695-699.

Comparative Genetics of Sweet Taste in Carnivora. Consultant. PA-09-058-Structural Analysis of The ligand-Binding. Properties of Taste and Smell Receptors. 2010-2015. (R01DC010842-01A1)