Biographies

Yu Lan, PhD

Associate Professor, UC Department of Surgery

UC Department of Pediatrics

Phone: 513-803-7842

Email: yu.lan@cchmc.org

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Biography

Yu Lan, PhD, is a developmental geneticist interested in understanding the genetic basis and developmental mechanisms of structural birth defects. Cleft palate is one of the most common birth defects in humans. To understand the molecular and cellular mechanisms of cleft palate pathogenesis, we have been investigating the molecular pathways governing normal palate development in the laboratory mice.

Through gene expression screening, we have identified several putative transcription factor genes with distinct and dynamic expression patterns in the developing mouse palate. Using the gene targeting technology, we have generated mice carrying null or conditional null mutations in some of these transcription factor genes. Analyses of the mutant mice revealed that several of these transcription factors, such as Osr1 and Osr2, play essential roles in palate development. Ongoing investigations focus on delineating the molecular pathways involving these factors in palate development using a combination of genetic, embryological, and biochemical approaches.

Education and Training

PhD: University of Maine, Orono, ME.

Post-doc training: Wesleyan University, Middletown, CT; The Jackson Laboratory, Bar Harbor, ME.

Publications

Grants

Molecular Genetic Analysis of Craniofacial Development. Co-Investigator. National Institutes of Health. Apr 2000 - Jun 2015. #R01 DE013681.