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Biographies

Find another Doctor or Researcher

High Res

Anil Mishra, PhD

Associate Professor, UC Department of Pediatrics

Phone: 513-636-3347

Fax: 513-636-3310

Email: anil.mishra@cchmc.org

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Specialties

Pulmonary and esophageal inflammationl; eosinophilic esophagitis; aeroallergen-induced allergic responses in the lung and gastrointestinal tract

Biography

Anil Mishra, PhD, scientific objective includes elucidating the mechanism for the recruitment of inflammatory cells into the mucosal allergic tissue. Dr. Mishra is actively involved in managing a research program focused on understanding the molecular mechanisms of eosinophilic esophageal and lower gastrointestinal tract inflammation.

Dr. Mishra's important contribution was to establish that eosinophils are the resident cell that home prenatally in the gastrointestinal tract and the gastrointestinal tract (esophagus to colon) constitutively expresses eotaxin (an eosinophil selective chemoattractant). These finding indicated that the esophagus is devoid of resident eosinophils at baseline and eotaxin is not sufficient for eosinophil trafficking and homing into the tissues.

In an effort to further understand the mechanisms and significance of eosinophil accumulation in the lung and esophagus at disease states, Dr. Mishra prioritized his research to focus on lung inflammation associated eosinophilic esophagitis, aiming to gain insight into this poorly understood disease. He developed a murine model of asthma associated eosinophilic esophagitis. These findings implicated aeroallergens in the etiology of EE and suggested that esophageal eosinophilic inflammation is mechanistically associated with pulmonary inflammation.

Recently, Dr. Mishra showed that CD4 T cells dependency is less important in the esophageal eosinophilic inflammation compared to the lung and IL-5 induced esophageal eosinophilia promotes tissue remodeling. Dr. Mishra's is an elected fellow of the American Academy of Allergy, Asthma and Immunology and the American Association of Gastroenterology. He has over a 50 articles on molecular mechanisms of the pulmonary toxicity and allergic responses. His research has been supported by the National Institutes of Health to understand the mechanism that induce eosinophilic esophagitis.

Education and Training

PhD: Kanpur University, Kanpur, India.

Publications

View PubMed Publications

Rayapudi M, Mavi P, Zhu X, Pandey AK, Abonia JP, Rothenberg ME, Mishra A. Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2010 Aug;88(2):337-46.

Zhu X, Wang M, Mavi P, Rayapudi M, Pandey AK, Kaul A, Putnam PE, Rothenberg ME, Mishra A. Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice. Gastroenterology. 2010 Jul;139(1):182-93.e7.

Zhu X, Wang M, Crump CH, Mishra A. An imbalance of esophageal effector and regulatory T cell subsets in experimental eosinophilic esophagitis in mice. Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G550-8.

Mishra A. Mechanism of eosinophilic esophagitis. Immunol Allergy Clin North Am. 2009 Feb;29(1):29-40, viii. Review.

Palumbo JS, Barney KA, Blevins EA, Shaw MA, Mishra A, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL. Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function. J Thromb Haemost. 2008 May;6(5):812-9.

Mishra A, Wang M, Pemmaraju VR, Collins MH, Fulkerson PC, Abonia JP, Blanchard C, Putnam PE, Rothenberg ME. Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology. 2008 Jan;134(1):204-14.

Mishra A, Wang M, Schlotman J, Nikolaidis NM, DeBrosse CW, Karow ML, Rothenberg ME. Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L305-13.

Mishra A, Schlotman J, Wang M, Rothenberg ME. Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2007 Apr;81(4):916-24.

Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rothenberg ME. Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol. 2006 Jul;118(1):257-68.

Akei HS, Brandt EB, Mishra A, Strait RT, Finkelman FD, Warrier MR, Hershey GK, Blanchard C, Rothenberg ME. Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses. J Allergy Clin Immunol. 2006 Jul;118(1):62-9.