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High Res

Bradley S. Marino, MD, MPP, MSCE

Attending Cardiac Intensivist, Cardiac Intensive Care Unit

Director, Heart Institute Research Core

Director, Heart Institute Neurodevelopmental Clinic

Associate Professor, UC Department of Pediatrics

Phone: 513-636-8254

Fax: 513-803-0370

Email: bradley.marino@cchmc.org

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Specialties

Clinical Interests

Cardiac intensive care; single ventricle physiology; aortic and mitral valve disease; cardiopulmonary interaction

Research Interests

Intensive care outcomes; quality of life assessment in children and adolescents with congenital and acquired heart disease; aortic valve and mitral valve surgical outcomes; cardiopulmonary interaction (shock and cardiac arrest).

Biography

Bradley S. Marino, MD, MPP, MSCE is an Associate Professor of Pediatrics with the University of Cincinnati College of Medicine and an attending cardiac intensivist in Cincinnati Children’s Hospital Medical Center’s (CCHMC) Cardiac Intensive Care Unit. Dr. Marino is also currently the Director of the Heart Institute Research Core and the Director of Heart Institute Neurodevelopmental Clinic at CCHMC.

A native of New York, Dr. Marino graduated with Honors from University of Virginia and earned his medical degree from Harvard Medical School in 1994. He completed his pediatric residency at Johns Hopkins Hospital and a combined fellowship in Cardiology and Critical Care Medicine at The Children’s Hospital of Philadelphia. Dr. Marino’s clinical interests are focused on outcomes in infants, neonates, children, and adolescents with complex congenital heart disease (CHD). In addition Dr. Marino received a Master’s degree in Public Policy from the John F. Kennedy School of Government at Harvard University in 1994 and a Master’s of Science degree in Clinical Epidemiology from the Center for Clinical Epidemiology and Biostatistics at University of Pennsylvania in 2005.

Dr. Marino has been a faculty member in the divisions of Cardiology and Critical Care Medicine at CCHMC since 2007. Upon his arrival, he led the development of HIRC, an innovative platform that supports clinical and translational science by facilitating the design of research processes, implementation of research plans, dissemination and application of findings, and development of research professionals. HIRC presently provides support to more than 75 principal investigators on 180 clinical and translational research projects.

Dr. Marino has focused his own research efforts on the impact of neurodevelopmental, psychosocial, and physical morbidities on quality of life, functional status, and behavioral and emotional outcomes in the high-risk complex congenital heart disease population. He is the creator of the Pediatric Cardiac Quality of Life Inventory (PCQLI), a validated disease-specific health-related quality of life tool and was awarded several intramural and extramural training grants to test the psychometric properties of the PCQLI in the multi-center, multi-national PCQLI Validation Study in the United States and the United Kingdom. To address the lower quality of life associated with patients with severe heart disease, Dr. Marino spearheaded the creation of the Heart Institute Neurodevelopmental Clinic (NDC) in 2011. The NDC multi-disciplinary team consists of cardiologists, cardiovascular geneticists, neurologists, developmental pediatricians, psychologists, educators, occupational therapists, nutritionists, and social workers who address neurodevelopmental issues that impact learning, psychological and social functioning and physical functioning. It is one of few clinics of its kinds in the US for “high-risk” children with heart disease.

Dr. Marino’s expertise in the field of outcomes research in pediatric cardiology has led to many presentations, publications, and invitations to serve on national expert committees including American Heart Association’s Emergency Cardiac Care Pediatric Subcommittee and Pediatric Cardiac Intensive Care Society Board of Directors. Dr. Marino has been recognized in Cincy Magazine: Best Doctors in America – Pediatric Cardiology Pediatric Critical Medicine in 2008, 2009, 2010 and 2011.

Education and Training

MD: Harvard Medical School, Boston, MA, 1994.

MPP: Harvard University/John F. Kennedy School of Government (Masters in Public Policy - Health Care Policy), Boston, MA, 1994.

MSCE: University of Pennsylvania/Center for Clinical Epidemiology and Biostatistics, (Master of Science in Clinical Epidemiology), Philadelphia, PA, 2005.

Residency: Pediatrics, Johns Hopkins Hospital, Baltimore, MD, 1997.

Fellowships: Combined Pediatric Cardiology and Pediatric Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, 2002.

Certification:
American Board of Pediatrics 1997, Recertification 2004;
Sub-Board of Pediatric Cardiology 2000;
Sub-Board of Pediatric Critical Care Medicine 2002.

Publications

View PubMed Publications

Goldberg D, French B, Szwast AL, McBride MG, Marino BS, Mirarchi N, Hanna BD, Wernovsky G, Paridon SM, Rychik J. Impact of sildenafil on echocardiographic indices of myocardial performance after the Fontan operation. Pediatric Cardiology 2012 (In Press)

Anderson J, Czosek RJ, Uzark K, Knilans TK, Marino BS. The effect of pediatric syncope on quality of life. Cardiol Young 2012 (In Press)

Wray J, Franklin R, Brown K, Blyth J, Marino BS. Linguistic validation of a disease-specific quality of life measure for children and teenagers with cardiac disease. Cardiol Young 2012; 22(1):13-17.

Wray J, Brown K, Rodney F, Marino BS. Medical test results don’t tell the whole story: health-related quality of life offers a patient perspective on outcomes. WJPCHS2011; 2(4):566-575.

Metzger A, Matsuura T, McKnite S, Marino BS, Nadkarni V, Lurie K, Yannopoulos D. Intrathoracic pressure regulation improves 24-hour survival in a pediatric porcine model of hemorrhagic shock. Pediatric Research 2011; 70(3):267-271.

Goldberg DJ, French B, McBride MG, Marino BS, Mirarchi N, Hanna BD, Wernovsky G, Paridon SA, Rychik J. Impact of oral sildenafil on exercise performance in children and young adults after Fontan operation: a randomized, double-blind, placebo controlled, crossover trial. Circulation 2011; 123:1185-1193.

Anderson JB, Kalkwarf HJ, Kehl JE, Eghtesady P, Marino BS. Low weight-for-age Z-score and infection risk following Fontan procedure. Annals Thorac Surg 2011; 91(5):1460-1466.

Anderson JB, Marino BS, Irving SY, García-España JF, Ravishankar C, Stallings VA, Medoff-Cooper B. Poor post-operative growth in infants with two-ventricle physiology. Cardiol Young. 2011 Mar 9:1-9.

Anderson JB, Kalkwarf HJ, Kehl JE, Eghtesady P, Marino BS. Low Weight-for-Age Z-Score and Infection Risk After the Fontan Procedure. Ann Thorac Surg. 2011 Mar 4.

Goldberg DJ, French B, McBride MG, Marino BS, Mirarchi N, Hanna BD, Wernovsky G, Paridon SA, Rychik J. Impact of Oral Sildenafil on Exercise Performance in Children and Young Adults After Fontan Operation: A Randomized, Double-Blind, Placebo Controlled, Crossover Trial. Circulation. 2011 Mar 7.

Marino BS, Drotar D, Cassedy A, Davis R, Tomlinson RS, Mellion K, Mussatto K, Mahony L, Newburger JW, Tong E, Cohen MI, Helfaer MA, Kazak AE, Wray J, Wernovsky G, Shea JA, Ittenbach R. External Validity of the Pediatric Cardiac Quality of Life Inventory. Quality of Life Research. 2011 Mar;20(2):205-14.

Manning PB, Rutter MJ, Lisec A, Gupta R, Marino BS. One slide fits all: the versatility of slide tracheoplasty with cardiopulmonary bypass support for airway reconstruction in children. J Thorac Cardiovasc Surg. 2011 Jan;141(1):155-61.

Marino BS, Tomlinson RS, Wernovsky G, Drotar D, Newburger JW, Mahony L, Mussatto K, Tong E, Cohen M, Andersen C, Shera D, Khoury P, Wray J, Gaynor WJ, Helfaer MA, Kazak AE, Shea JA. Evaluation of Health-related Quality of Life in Children and Adolescents with Congenital or Acquired Heart Disease: Validation of the Pediatric Cardiac Quality of Life Inventory. Pediatrics. 2010;126:1-11.

Kleinman ME, Chameides L, Schexnayder SM, Samson RA, Hazinski MF, Atkins DL, Berg MD, de Caen A, Fink E, Freid E, Hickey R, Marino BS, Nadkarni VM, Proctor L, Qureshi F, Sartorelli K, Topjian A, van der Jagt E, Zaritsky AL. Pediatric Advance Life Support. Circulation. 2010;122(18 Suppl 3):S876-S908.

Marino BS, Tomlinson RS, Drotar D, Claybon ES, Aguirre A, Ittenbach R, Welkom JS, Helfaer MA, Wernovsky G, Shea JA. Quality-of-life concerns differ among patients, parents, and medical providers in children and adolescents with congenital and acquired heart disease. Pediatrics. 2009;123(4):e708-15.

Marino BS, Shera D, Wernovsky G, Tomlinson RS, Aguirre A, Gallagher M, Lee A, Cho C, Stern W, Davis L, Tong E, Teitel D, Mussatto K, Ghanayem N, Gleason, M, Gaynor JW, Wray J, Helfaer MA, Shea JA. The development of the Pediatric Cardiac Quality of Life Inventory: a quality of life measure for children and adolescents with heart disease. Quality of Life Research. 2008;17(4):613-626.

Marino BS, Kruge LE, Cho CJ, Tomlinson RS, Shera D, Weinberg PM, Gaynor JW, Rychik J. Parachute mitral valve: morphologic descriptors, associated lesions, and outcomes after biventricular repair. J Thorac Cardiovasc Surg. 2008;137:385-393.

Grants

Outcomes Research in Children with Complex Congenital Heart Disease. Principal Investigator. Cincinnati Children’s Hospital Research Foundation. 7/1/07-6/30/12

Do Serum Biochemical and Hematopoietic, and Stool Biomarkers Predict Low Cardiac Index in Patients with Fontan Physiology? Principal Investigator. Children’s Heart Foundation. 1/1/12-12/31/13

Transitional Telehealth Home Care: REACH. Site Principal Investigator. National Institute of Nursing Research. 9/21/11-6/30/16

Understanding Mechanisms of Fontan Failure and Key Predictors for Patient Outcome. Collaborator. NIH/NHLBI. 2/01/10-1/31/14