Eric Mullins, MD

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4266

Fax 513-636-3549

Email eric.mullins@cchmc.org

Clinical

Dr. Mullins is interested in the care of children and adolescents with bleeding and thrombotic disorders, especially Hemophilia and von Willebrand’s Disease. In collaboration with Pediatric Gynecology, Dr. Mullins started the Young Women’s Bleeding Disorder Clinic, to better serve young women who have disordered menstrual bleeding. Dr. Mullins is the research director of the Hemophilia Treatment Center.

Research

Dr. Mullins’s lab focuses on the interaction of coagulation factors with immunity and inflammation. Dr. Mullins has specifically focused on two inflammatory diseases, multiple sclerosis and sickle cell disease. His laboratory utilizes mouse models of these diseases in conjunction with coagulation factor knockouts to understand how hemostatic factors modify the inflammatory response.

MD: University of Missouri, Columbia.

Residency: Vanderbilt University Medical Center, Nashville, TN, 2001-2004.

Fellowship: Pediatric Hematology / Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004-2007; Pediatric Hemostasis Fellowship, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2007-2008; Chief Fellow, Pediatric Hematology / Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2007-2008.

Board Certifications: Pediatrics, 2004-Present; Pediatric Hematology/Oncology, 2009-Present.

Raghu H, Cruz C, Rewerts CL, Frederick MD, Thornton S, Mullins ES, Schoenecker JG, Degen JL, Flick MJ. Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion. Blood. 2014 Oct 21.

Huang Y, Shaw MA, Mullins ES, Kirley TL, Ayres N. Synthesis and anticoagulant activity of polyureas containing sulfated carbohydrates. Biomacromolecules. 2014 Oct 20.

Turpin B, Miller W, Rosenfeldt L, Kombrinck K, Flick MJ, Steinbrecher KA, Harmel-Laws E, Mullins ES, Shaw M, Witte DP, Revenko A, Monia B, Palumbo JS. Thrombin drives tumorigenesis in colitis-associated colon cancer. Cancer Res. 2014 Jun 1;74(11):3020-30.

Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol. 2014 Feb;75(2):303-8.

Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KT, Mullins ES, Flick MJ, Queiroz KCS, Speck CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo J. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood. 2011;118:2889-95.

Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood. 2011;117:6326-37.

Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood. 2009;113:676-704.