Halima Moncrieffe, PhD

Instructor, UC Department of Pediatrics

Phone 513-636-4676

Email halima.moncrieffe@cchmc.org

Immunoregulation; juvenile idiopathic arthritis; biomarkers of response to medication

Halima Moncrieffe, PhD, is an immunologist who has basic and translational research interests in mechanisms of childhood arthritis susceptibility and immunopathology. She studies how genetic and immunological variants contribute to inflammation and response to medication. A second research focus is investigating mechanisms of immune system suppression with specific interest in regulatory T cell function.

PhD: Imperial College London, London, United Kingdom.

Cobb J*, Cule E*, Moncrieffe H*, Hinks A,  Ursu S, Patrick F, Kassoumeri L, Flynn E, Bulatović M, Wulffraat N, van Zelst B, de Jonge R, Bohm M, Dolezalova P, Hirani S, Newman S, Whitworth P, Southwood TR, De Iorio M; Childhood Arthritis Response to Medication Study (CHARMS), Childhood Arthritis Prospective Study (CAPS), BSPAR study group, Wedderburn LR, Thomson W (*joint first authors). Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. Pharmacogenomics J. 2014 Apr 8. Epub ahead of print.

Moncrieffe H, Ursu S, Holzinger D, Patrick F, Kassoumeri L, Wade A, Roth J, Wedderburn LR. A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein. Rheumatology (Oxford). 2013 Aug;52(8):1467-76.

Mulligan K, Kassoumeri L, Etheridge A, Moncrieffe H, Wedderburn LR, Newman S. Mothers’ reports of the difficulties that their children experience in taking methotrexate for Juvenile Idiopathic Arthritis and how these impact on quality of life. Pediatr Rheumatol Online J. 2013 May 28;11(1):23.

Hamaoui R, Omoyinmi E, Pesenacker A, Nistala K, Moncrieffe H, Ursu S, Wedderburn LR, Woo P. Th1 and Th17 cell subpopulations are enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis. Rheumatology (Oxford). 2012 Oct;51(10):1881-6.

Holzinger D, Frosch, M, Kastrup, A, Prince FH, Otten, MH, Suijlekom-Smit LW, ten Cate R, Hoppenreijs EP, Hansmann S, Moncrieffe H, Ursu S, Wedderburn LR, Roth J, Foell D, Wittkowski H. The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in Systemic-Onset Juvenile Idiopathic Arthritis. Ann Rheum Dis. 2012 Jun;71(6):974-80.

Hinks A, Moncrieffe H, Martin P, Ursu S, Lal S, Kassoumeri L, Weiler T, Glass DN, Thompson SD, Wedderburn LR, Thomson W. Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC) gene with response to methotrexate in juvenile idiopathic arthritis (JIA). Ann Rheum Dis. 2011 Aug;70(8):1395-400.

Moncrieffe H, Wedderburn LR. Regulatory T cells in Arthritis: Why Do They Fail? In Hayashi RS (Ed) Regulatory T cells. Nova Biomedical: New York 2011

Moncrieffe H, Hinks A, Ursu S, Kassoumeri L, Etheridge A, Hubank M, Martin P, Weiler T, Glass DN, Thompson SD, Thomson W, Wedderburn LR. Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype. Pharmacogenet Genomics. 2010 Nov;20(11):665-76.

Moncrieffe H, Nistala K, Kamhieh Y, Evans J, Eddaoudi A, Eaton S, Wedderburn LR. High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population. J Immunol. 2010 Jul 1;185(1):134-43.

Moncrieffe H, Coles M, Atkins C, Stockinger B. The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated-graft-versus-host disease. Immunology. 2008 Dec;125(4):459-68.