Jarek Meller, PhD

Graduate Program Director, Division of Biomedical Informatics

Associate Professor, UC Department of Environmental Health

Phone 513-636-0270

Fax 513-636-2056

Email jmeller@cchmc.org

Building upon broad interdisciplinary training in molecular modeling, computational chemistry, and bioinformatics, Dr. Meller has been pursuing research at the intersection of computational genomics and biomedicine. He and his group have developed a number of successful methods for the prediction of protein structure, protein-protein interactions and functional hot spots in proteins. Several web servers developed by the group, including Sable, Sppider, Minnou and Polyview have widely been used, with a total of over 900,000 submissions from more than 30,000 users in many countries. He has been active in the development and applications of methods for knowledge extraction from high dimensional genomic data. Dr. Meller and his group have also been involved in many collaborative projects with direct medical relevance. Examples of such interdisciplinary efforts include sequencing and annotation of human pathogens, identification of markers associated with disease subtypes in cancer and autoimmunity, modeling of signal transduction pathways in differentiation and development, developing inhibitors of critical protein-protein interactions in autophagy, bone marrow transplants, and pathogen-host interactions.

Dr. Meller has been broadly involved in quantitative and computational training efforts within UC’s College of Medicine and College of Engineering and Applied Sciences, leading several inter-departmental and inter-collegiate initiatives in this regard. Dr. Meller serves as the director of the newly created PhD program in biomedical informatics at UC, co-director of the Biomedical Informatics Graduate Certificate Program, and has been involved in several informatics and quantitative training efforts at UC College of Medicine. Dr. Meller is the co-director of the Bioinformatics Core for the Center of Environmental Genetics at the University of Cincinnati. He also serves as the director of Protein Informatics Core at Cincinnati Children’s Hospital Medical Center.

PhD: Biomedical Engineering, Polish Academy of Sciences, Warsaw, 2004.

View Publications on Google Scholar

Kesarwani M, Huber E, Kincaid Z, Evelyn CR, Biesiada J, Rance M, Thapa MB, Shah NP, Meller J, Zheng Y, Azam M. Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. Sci Rep. 2015 Sep 30;5:14538.

Walther A, Mohanty SK, Donnelly B, Coots A, Lages CS, Lobeck I, Dupree P, Meller J, McNeal M, Sestak K, Tiao G. Rhesus rotavirus VP4 sequence-specific activation of mononuclear cells is associated with cholangiopathy in murine biliary atresia. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G466-74.

Chen SH, Meller J, Elber R. Comprehensive analysis of sequences of a protein switch. Protein Sci. 2015 Jun 12.

Evelyn CR, Biesiada J, Duan X, Tang H, Shang X, Papoian R, Seibel WL, Nelson S, Meller J, Zheng Y. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290(20):12879-98.

Tam NN, Zhang X, Xiao H, Song D, Levin L, Meller J, Ho SM. Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model. Lab Invest. 2015 May;95(5):546-60.

Sadhasivam S, Zhang X, Chidambaran V, Mavi J, Pilipenko V, Mersha TB, Meller J, Kaufman KM, Martin LJ, McAuliffe J. Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects. Pharmacogenomics J. 2015 Oct;15(5):436-42.

Hall DP, Cost NG, Hegde S, Kellner E, Mikhaylova O, Stratton Y, Ehmer B, Abplanalp WA, Pandey R, Biesiada J, Harteneck C, Plas DR, Meller J, Czyzyk-Krzeska MF. TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma. Cancer Cell. 2014 Nov 10;26(5):738-53.

Biesiada J, Chidambaran V, Wagner M, Zhang X, Martin LJ, Meller J, Sadhasivam  S. Genetic risk signatures of opioid-induced respiratory depression following pediatric tonsillectomy. Pharmacogenomics. 2014 Nov;15(14):1749-1762.

Evelyn CR, Duan X, Biesiada J, Seibel WL, Meller J, Zheng Y. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chem Biol. 2014 Dec 18;21(12):1618-28.

Johansson E, Reponen T, Meller J, Vesper S, Yadav J. Association of Streptomyces community composition determined by PCR-denaturing gradient gel electrophoresis with indoor mold status. Environ Monit Assess. 2014 Dec;186(12):8773-83.