Jun Ma, PhD

Professor, UC Department of Pediatrics

Phone 513-636-7977

Fax 513-636-4317

Email jun.ma@cchmc.org

Molecular mechanisms of gene regulation and embryonic development

Research performed by Dr. Ma’s team focuses on understanding developmental processes at a quantitative and systems level. His team investigates fundamental mechanisms of development through a combination of quantitative experimental approaches and theoretical and simulation approaches. One major focus of Ma’s lab concerns the questions of how morphogen gradients are established, and how precise positional information is encoded by these gradients and interpreted by cells in developing tissues. In a recent study that the team reported in a Nature Communications paper (2015), they establish a mathematical model to quantitatively connect two different stages of the life cycle of the fruit fly Drosophila: oocyte formation and embryonic pattern specification. Their reported study provides a fresh view of how the resources are accumulated by the mother for the purpose of instructing robust development of the future embryo.

BS: Peking University, 1978-1982.

PhD: Harvard University, Cambridge, MA, 1983-1988 (degree awarded 1990).

View PubMed Publications

Wu H, Manu Jiao R, Ma J. Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila. Nat Commun. 2015.

Liu J, Ma J. Modulation of temporal dynamics of gene transcription by activator potency in the Drosophila embryo. Development. 2015;142:3781-3790.

Cheung D, Ma J. Probing the impact of temperature on molecular events in a developmental system. Sci Rep. 2015;5:13124.

He F, Wei C, Wu H, Cheung D, Jiao R, Ma J. Fundamental origins and limits for scaling a maternal morphogen gradient. Nat Commun. 2015;6:6679.

Cheung D, Miles C, Kreitman M, Ma J. Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos. Development. 2014;141(1):124-135.

Liu J, Ma J. Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila. Nat Commun. 2013;4:2968.

He F, Ren J, Wang W, Ma J. Evaluating the Drosophila Bicoid morphogen gradient system through dissecting the noise in transcriptional bursts. Bioinformatics. 2012;28:970-975. 

Liu J, Ma J. Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos. Nat Cell Biol. 2011 Jan;13(1):22-9.

Cheung D, Miles C, Kreitman M, Ma J. Scaling of the Bicoid morphogen gradient by a volume-dependent production rate. Development. 2011;138:2741-2749.

He F, Wen Y, Deng J, Lin X, Lu LJ, Jiao R, Ma J. Probing intrinsic properties of a robust morphogen gradient in Drosophila. Dev Cell. 2008 Oct;15(4):558-67.