Keith Marsolo, PhD

Associate Professor, UC Department of Pediatrics

Phone 513-803-0333

Fax 513-636-2056


Dr. Keith Marsolo is an associate professor in the Division of Biomedical Informatics. He led the implementation of Cincinnati Children's research data warehouse, which utilizes a custom version of the open-source i2b2 framework. The software allows users to perform de-identified cohort queries, request datasets or biosamples for research purposes, and in select cases, perform de-identified chart review. Dr. Marsolo and his team have developed several other stand-alone applications that interface with the EHR, including a tool that supports Cincinnati Children's research biobank. At the time of registration, patients are asked whether they would allow their residual clinical samples to be kept for research purposes. The tool allows biobank personnel to query a sample and then determine, based on the patient’s consent decision and several other factors, whether it can be kept for research.

Dr. Marsolo is also heavily involved in the creation of data collection and reporting systems to support multi-center quality improvement and research networks, as well as query tools for a number of other federated data sharing networks. Most recently, led the design and development of an EHR-linked "enhanced" registry for ImproveCareNow, a multi-center collaborative focused on improving care and outcomes for children with inflammatory bowel disease. The registry allows users to collect data directly in the EHR, where it can then be uploaded to the registry and used in a number of different automated reports. Much of his most recent work involves projects to support the development and implementation of the PCORI National Patient-Center Clinical Research Network. Dr. Marsolo earned a bachelor’s in computer science and engineering, a master’s in biomedical engineering and in computer and information science, and a PhD in computer and information science from The Ohio State University.

BS: Computer Science and Engineering, The Ohio State University, Columbus, OH, 2002.

MS: Biomedical Engineering, The Ohio State University, Columbus, OH, 2005; Computer and Information Science, The Ohio State University, Columbus, OH, 2006.

PhD: Computer and Information Science, The Ohio State University, Columbus, OH, 2007.

View PubMed Publications

Marsolo K, Spooner SA. Clinical genomics in the world of the electronic health recordGenet Med. 2013 Oct; 15(10):786-91.

Bonafide CP, Brady PW, Keren R, Conway PH, Marsolo K, Daymont C. Development of Heart and Respiratory Rate Percentile Curves for Hospitalized Children. Pediatrics. 2013 Apr;131(4):e1150–7.

Natter MD, Quan J, Ortiz DM, Bousvaros A, Ilowite NT, Inman CJ, Marsolo K, McMurry AJ, Sandborg CI, Schanberg LE, Wallace CA, Warren RW, Weber GM, Mandl KD. An i2b2-based, Generalizable, Open Source, Self-scaling Chronic Disease Registry. J Am Med Inform Assoc.  2013 Jan 1;20(1):172-9.

Marsolo K. Informatics & operations – let’s get integratedJ Am Med Inform Assoc.  2013 Jan 1;20(1):122-4.

Deleger L, Molnar K, Savova G, Xia F, Lingren T, Li Q, Marsolo K, Jegga A, Kaiser M, Stoutenborough L, Solti I. Large-scale evaluation of automated clinical note de-identification and its impact on information extraction. J Am Med Inform Assoc.  2013 Jan 1;20(1)84-94.

Marsolo K, Corsmo J, Barnes MG, Pollick C, Nix J, Chalfin J, Smith C, Ganta R. Challenges in Creating an Opt-in Biobank with a Registrar-based Consent Process and a Commercial EHR. J Am Med  Inform Assoc. 2012 Nov-Dec;19(6):1115-8.

Marsolo, K. In Search of a Data-in-Once, Electronic Health Record-Linked, Multicenter Registry— How Far We Have Come and How Far We Still Have to Go. eGEMs (Generating Evidence & Methods to improve patient outcomes). 2012 Dec:1(1), Article 3.

Marsolo, K. Approaches to Facilitate Institutional Review Board Approval of Multi-center Research StudiesMed Care. 2012 Jul;50 Suppl:S77-81.

Wen H, Marsolo KA, Bennett EE, Kutten KS, Lipps DB, Plehn JF, Epstein ND, Croisille P. Adaptive Postprocessing Techniques for Myocardial Tissue Tracking with Displacement-Encoded MR Imaging. Radiology.  2008 Jan;246(1):229-40.

Marsolo K, Twa M, Bullimore MA, Parthasarathy S. Spatial Modeling and Classification of Corneal Shape. IEEE Trans Inf Technol Biomed. 2007 Mar;11(2):203-12.