Keith Marsolo, PhD

Associate Professor, UC Department of Pediatrics

Phone 513-803-0333

Fax 513-636-2056


Dr. Keith Marsolo is an associate professor in the Division of Biomedical Informatics whose research interests include methods to characterize the quality and suitability of electronic health record (EHR) data, approaches to collect and extract research data from the EHR at scale, the design and instantiation of common data models to facilitate distributed research queries, and the development of informatics architectures and standards that can support multi-center learning health systems. He serves as faculty advisor for BMI Data Services, which has specialized expertise in these areas.

Dr. Marsolo led the implementation of Cincinnati Children's research data warehouse, which utilizes a custom version of the open-source i2b2 framework, allowing users to perform de-identified cohort queries. Dr. Marsolo and his team have developed several other stand-alone applications that interface with the EHR, including a tool that supports Cincinnati Children's research biobank. Dr. Marsolo and his team are also heavily involved in development of systems to support multi-center learning health systems, and in using EHR data to instantiate common data models that can be queried through distributed research networks. Dr. Marsolo and his team successfully completed an extension grant from the Agency for Healthcare Research and Quality that builds on their previous implementation of an EHR-linked registry for ImproveCareNow. Dr. Marsolo and his team are also involved in the implementation of PCORI’s National Patient-Centered Clinical Research Network (PCORnet). They are participating in a pediatric-focused Clinical Data Research Network (CDRN), and a Patient-Powered Research Network (PPRN) with ImproveCareNow. Dr. Marsolo also served as one of the co-chairs of the PCORnet’s Data Standards, Security and Network Infrastructure (DSSNI) Task Force during the first phase of PCORnet.

BS: Computer Science and Engineering, The Ohio State University, Columbus, OH, 2002.

MS: Biomedical Engineering, The Ohio State University, Columbus, OH, 2005; Computer and Information Science, The Ohio State University, Columbus, OH, 2006.

PhD: Computer and Information Science, The Ohio State University, Columbus, OH, 2007.

View PubMed Publications

Marsolo K, Margolis PA, Forrest CB, Colletti RB, Hutton JJ. A Digital Architecture for a Network-Based Learning Health System – Integrating Chronic Care Management, Quality Improvement, and Research. eGEMs (Generating Evidence & Methods to improve patient outcomes). 2015 Aug 17;3(1):1168.

Forrest C, Crandall W, Bailey C, Zhang P, Joffe M, Colletti R, Adler J, Baron H, Berman J, DelRosario F, Grossman A, Hoffenberg E, Israel E, Kim S, Lightdale JR, Margolis P, Marsolo K, Mehta D, Milov D, Patel A, Tung J, Kappelman M. Effectiveness of Anti-TNFα for Crohn’s Disease: Research in a Pediatric Learning Health System. Pediatrics. 2014 Jul;134(1):37-44.

Forrest CB, Margolis PA, Bailey LC, Marsolo K, Del Beccaro MA, Finkelstein JA, Milov DE, Vieland VJ, Wolf BA, Yu FB, Kahn MG. PEDSnet: a National Pediatric Learning Health System. J Am Med Inform Assoc. 2014 Jul;21(4):602-606.

Mandl KD, Kohane IS, McFadden D, Weber GM, Natter N, Mandel J, Schneeweiss S, Weiler S, Klann JG, Bickel J, Adams WG, Ge Y, Zhou X, Perkins J, Marsolo K, Bernstam E, Showalter J, Quarshie A, Ofili E, Hripcsak G, Murphy SN. Scalable Collaborative Infrastructure for a Learning Healthcare System (SCHILS): Architecture. J Am Med Inform Assoc. 2014 Jul;21(4):615-620.

Deleger L, Lingren T, Ni Y, Kaiser M, Stoutenborough L, Marsolo K, Kouril M, Solti I. Preparing an annotated gold standard corpus to share with extramural investigators for de-identification research. J Biomed Inform. 2014 Aug;50:173-83. 

Marsolo K, Spooner SA. Clinical genomics in the world of the electronic health record. Genet Med. 2013 Oct; 15(10):786-91.

Natter MD, Quan J, Ortiz DM, Bousvaros A, Ilowite NT, Inman CJ, Marsolo K, McMurry AJ, Sandborg CI, Schanberg LE, Wallace CA, Warren RW, Weber GM, Mandl KD. An i2b2-based, Generalizable, Open Source, Self-scaling Chronic Disease Registry. J Am Med Inform Assoc.  2013 Jan 1;20(1):172-9.

Marsolo K. Informatics & operations – let’s get integrated. J Am Med Inform Assoc.  2013 Jan 1;20(1):122-4.

Deleger L, Molnar K, Savova G, Xia F, Lingren T, Li Q, Marsolo K, Jegga A, Kaiser M, Stoutenborough L, Solti I. Large-scale evaluation of automated clinical note de-identification and its impact on information extraction. J Am Med Inform Assoc.  2013 Jan 1;20(1)84-94.

Marsolo K. In Search of a Data-in-Once, Electronic Health Record-Linked, Multicenter Registry— How Far We Have Come and How Far We Still Have to Go. EGEMS (Wash DC). 2013 Jan 17;1(1):1003.