Lisa J. Martin, PhD

Professor, UC Department of Pediatrics

Phone 513-636-1244

Fax 513-636-7509

Email lisa.martin@cchmc.org

Research

Statistical genetics; allergic conditions; pediatric heart conditions; obesity

As a statistical geneticist, Dr. Martin’s goal is to advance knowledge of underlying disease processes by improving our understanding of genetic variation in human populations through the integration of statistical genetics with biology and epidemiology. Since joining Cincinnati Children’s in 2002, Dr. Martin has become a leader in quantitative genetics through independent and collaborative research, leadership, and teaching/mentoring. Her independent research focuses on development of novel statistical methods and the evaluation of methods for next generation data. 

Recently, Dr. Martin published a novel statistical method (Variant Impact On Linkage Effect Test; VIOLET), which overcomes a methodological barrier to gene discovery.   Her collaborative research focuses on allergic conditions (asthma, eosinophilic esophagitis), pediatric heart conditions, and obesity.  In addition, Dr. Martin assists researchers with an interest in incorporating genetics into their research.   At the end of 2013, Dr. Martin had published 116 peer-reviewed publications (journals include Nature Genetics, PNAS, Journal of Clinical Endocrinology and Metabolism) and 2 book chapters.

She has a strong commitment to teaching and mentorship. Beyond teaching, she has mentored over 30 individuals. Additionally, Dr. Martin is the co-director of the Cincinnati Genomic Control Cohort, an institutional resource of 1,020 population representative children with phenotypic and genetic information.  Under Dr. Martin’s leadership, utilization of this cohort has increased. 

In summary, Dr. Martin’s work has resulted in the development of an exciting research program as well as fruitful collaborations while balancing mentoring and service.  She expects that this research will enable the translation of genetic findings to clinical utility through the development of innovative methods and greater capacity to perform complex genetic analyses particularly given the rapid evolution of technologies.

PhD: (with Honors) University of Kansas, Lawrence KS, 1999

Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio TX, 2002

Martin LJ, Ding L, Zhang X, Kissebah AH, Olivier M, Benson DW.  A novel method, the Variant Impact On Linkage Effect Test (VIOLET), leads to improved identification of causal variants in linkage regionsEur J Hum Genet. 2014 Feb;22(2):243-7.

Martin LJ, Gupta J, Jyothula SSSK, Butsch Kovacic M, Biagini Myers JM, Patterson TL, Ericksen MB, He H, Gibson AM, Baye TM, Amirisetty S, Tsoras AM, Sha Y, Eissa NT, Hershey GK.  Functional variant in the autophagy-related 5 gene promoter is associated with childhood asthma. PLoS One. 2012;7(4):e33454.

Kottyan LC, Woo JG, Keddache M, Banach W, Crimmins NA, Dolan LM, Martin LJ. Novel variations in the adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexesSpringerPlus. 2012 Dec;1(1):66.

Sadhasivam S,  Chidambaran C, Ngamprasertwong P, Esslinger HR, Prows C, Zhang X, Martin LJ, McAuliffe J. Race and unequal burden of perioperative pain and opioid related adverse effects in childrenPediatrics. 2012 May;129(5):832-8.

Martin LJ, Lee SY, Couch SC, Morrison J, Woo JG.  Shared genetic contributions of fruit and vegetable consumption with body mass index in families 20 years after sharing a householdAm J Clin Nutr. 2011 Oct;94(4):1138-43.

Martin LJ, Hinton RB, Zhang Z, Cripe LH, Benson DW.  Aorta measurements are heritable and influenced by bicuspid aortic valveFront Genet. 2011 Sep 5;2:61.

Martin LJ, Woo JG, Morrison JA. Evidence Of Shared Genetic Effects Between Pre And Post Obesity Epidemic BMI LevelsObesity. 2010 Jul;18(7):1378-82.

Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91.

Martin LJ, Ramachandran V, Cripe LH, Hinton RB, Andelfinger G, Tabangin M, Shooner K, Keddache M, Benson DW. Evidence in Favor of Linkage to Human Chromosomal Regions 18q, 5q and 13q for Bicuspid Aortic Valve and Associated Cardiovascular MalformationsHum Gen. 2007 Apr;121(2):275-84.

Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan LM. The Relationships of Adiponectin with Insulin and Lipids Are Strengthened with Increasing AdiposityJ Clin Endocrinol Metab. 2005 Jul;90(7):4255-9.