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Biographies

Find another Doctor or Researcher

High Res

Lisa J. Martin, PhD

Associate Professor, UC Department of Pediatrics

Phone: 513-636-1244

Fax: 513-636-7509

Email: lisa.martin@cchmc.org

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Specialties

Clinical Interests

Obesity; genetics; complex traits

Research Interests

The genetics of normal variation, obesity, reproduction, and asthma

Biography

Dr. Martin is an internationally recognized genetic epidemiologist. She has performed genetic analysis of complex traits for over 10 years and has published over 60 peer-reviewed publications (nearly half of which she is first or senior author) in prestigious journals including Nature Genetics, PNAS, and Diabetes. During her post-doctoral training, she received the James V. Neel Young Investigator Award for work on obesity genetics. At Cincinnati Children's, she received the Charlotte R. Schmidlapp Award for being an outstanding female investigator. Her research skills are further reflected in her grant funding; she held a PI on American Diabetes Association Career Development Award and has worked as co-I on multiple grants focusing on the genetics of complex traits.

At Cincinnati Children's, Dr. Martin provides statistical support for human genetic studies. She has been involved in family and population based genetic analyses by collaborating with numerous investigators. As part of this support, Dr. Martin assists in project planning, writing the statistical section of grant proposals, and assists with writing research papers. Recently, Dr. Martin has studied methodological considerations of genome wide association (GWA), especially how to reduce the number of false positives in the context of a million statistical tests1, 2. This work served as a basis for performing GWA at Cincinnati Children's. Indeed, she has designed several GWA studies under consideration for funding.

Education and Training

PhD: (with Honors) University of Kansas, Lawrence KS, 1999

Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio TX, 2002

Publications

View PubMed Publications

Baye TM, Martin LJ, Khurana Hershey GK. Application of genetic/genomic approaches to allergic disorders. J Allergy Clin Immunol. 2010 Sep;126(3):425-36; quiz 437-8.

Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis.J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3.

Doughty Rice C, Ruschman JG, Martin LJ, Manders JB, Miller E. Retrospective comparison of patient outcomes after in-person and telephone results disclosure counseling for BRCA1/2 genetic testing. Fam Cancer. 2010 Jun;9(2):203-12.

Bollepalli S, Dolan LM, Deka R, Martin LJ. Association of FTO gene variants with adiposity in African-American adolescents. Obesity (Silver Spring). 2010 Oct;18(10):1959-63.

Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis.Nat Genet. 2010 Apr;42(4):289-91.

Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010 Apr 1;184(7):4033-41.

Zarate YA, Martin LJ, Hopkin RJ, Bender PL, Zhang X, Saal HM. Evaluation of growth in patients with isolated cleft lip and/or cleft palate. Pediatrics. 2010 Mar;125(3):e543-9.

Tabangin ME, Woo JG, Martin LJ. The effect of minor allele frequency on the likelihood of obtaining false positives. BMC Proc. 2009 Dec 15;3 Suppl 7:S41.

Martin LJ, Gao G, Kang G, Fang Y, Woo JG. Improving the signal-to-noise ratio in genome-wide association studies. Genet Epidemiol. 2009;33 Suppl 1:S29-32.

Martin LJ, Woo JG, Morrison JA. Evidence of shared genetic effects between pre- and postobesity epidemic BMI levels. Obesity (Silver Spring). 2010 Jul;18(7):1378-82.

Grants

Genetic and Environmental Risk Factors for Hemorrhagic Stroke. Co-Investigator. National Institute of Health. Jul 2008 - Jun 2013. #R01NS036695.

Center Grant, Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program. Principal Investigator. National Institute of Health. Sep 206 - Aug 2011. #U19 A1070235.

Genetic Studies of Food Allergies Research Program: Candidate Gene Approach for Eosinophilic Esophagitis. Co-Investigator. Department of Defense. Mar 2010 - Feb 2012.

Pursing Perfection in Pediatric Therapeutics. Co-Investigator. National Institute of Health. Sep 2007 - Aug 2011. #U18 HS016957.

USAMRAAGenetic and Epigenetic Differences in Monozygotic Twins with NF1. Co-Investigator. Department of Defense. Jan 2010 - Dec 2011. #NF 093100.