Maxime M. Mahe, PhD

Adjunct Assistant Professor, UC Department of Surgery

maxime.mahe@cchmc.org

About

Biography

Prior to joining Cincinnati Children's Hospital Medical Center, Dr. Mahe performed his PhD research at the National Institute of Health and Medical Research in the Division of Neuropathies of the Enteric Nervous System and Digestive Diseases, in Nantes, France. His work emphasizes on understanding interactions between the enteric nervous system and intestinal epithelial cells.

In 2012, Dr. Mahe moved to Cincinnati Children's Hospital Medical Center to focus on the study of intestinal stem cells in the laboratory of Dr. Michael Helmrath. Since, he has been involved in collaborative studies aiming at understanding stem cell fate and gastrointestinal epithelial biology including the generation of functional human small intestine.

In 2015, Dr. Mahe became an instructor in the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's within the UC Department of Pediatrics. In 2017, he was recruited as an assistant professor at Inserm, France to establish a research program on the effects of the enteric nervous system on intestinal development using innovative approaches. Dr. Mahe is currently an adjunct assistant professor in the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's Hospital Medical Center.

Interests

Intestinal stem cells; pluripotent stem cells; neurogastroenterology; enteric nervous system; epithelial biology

Research Areas

General and Thoracic Surgery

Publications

UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking. Duclaux-Loras, R; Lebreton, C; Berthelet, J; Charbit-Henrion, F; Nicolle, O; de Courtils, CR; Waich, S; Valovka, T; Khiat, A; Rabant, M; et al. Journal of Clinical Investigation. 2022; 132.

Intestinal Organoids: New Tools to Comprehend the Virulence of Bacterial Foodborne Pathogens. Garcia, MA; Hillion, K; Cappelier, JM; Neunlist, M; Mahe, MM; Haddad, N. Foods. 2022; 11.

Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction. Siwczak, F; Loffet, E; Kaminska, M; Koceva, H; Mahe, MM; Mosig, AS. Frontiers in Immunology. 2021; 12.

Intestinal multicellular organoids to study colorectal cancer. Idris, M; Alves, MM; Hofstra, RM W; Mahe, MM; Melotte, V. Biochimica et Biophysica Acta - Reviews on Cancer. 2021; 1876.

Modeling Gastrointestinal Diseases Using Organoids to Understand Healing and Regenerative Processes. Ollivier, A; Mahe, MM; Guasch, G. Cells. 2021; 10.

PGI2 Inhibits Intestinal Epithelial Permeability and Apoptosis to Alleviate Colitis. Pochard, C; Gonzales, J; Bessard, A; Mahe, MM; Bourreille, A; Cenac, N; Jarry, A; Coron, E; Podevin, J; Meurette, G; et al. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1037-1060.

In Vivo Human PSC-Derived Intestinal Organoids to Study Stem Cell Maintenance. Vales, S; Poling, HM; Sundaram, N; Helmrath, MA; Mahe, MM. Methods in Molecular Biology. 2020; 2171:201-214.

Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity. Leonetti, D; Estephan, H; Ripoche, N; Dubois, N; Aguesse, A; Gouard, S; Brossard, L; Chiavassa, S; Corre, I; Pecqueur, C; et al. Cancer Research. 2020; 80:2651-2662.

Pluripotent stem cell derived intestinal organoids with an enteric nervous system. Loffet, E; Brossard, L; Mahe, MM. . 2020.

Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses. Lau, S; Li, Z; Lai, FP-L; Lui, KN-C; Li, P; Munera, JO; Pan, G; Mahe, MM; Hui, C; Wells, JM; et al. Gastroenterology. 2019; 157:1556-1571.e5.