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Michael L. Mucenski, PhD

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-3456


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Clinical Interests

Lung development, disease, and repair

Research Interests

My laboratory is interested in determining the role of the Wnt/beta-catenin signal transduction pathway in lung development, disease, and repair, using the mouse as a model system. We have generated mice that no longer express the beta-catenin gene or express an activated protein in specific epithelial cells of the lung. We have shown that beta catenin plays a critical role in proximal/distal patterning of the lung. Overexpression of an activated beta catenin protein causes airspace enlargement, tumorigenesis, goblet cell hyperplasia, and changes in the cell types that line the conducting airway. Through the use of microarray analysis we have identified a number of genes that may be directly regulated by beta-catenin. These studies will provide insight into signal transduction pathways that play key roles in the developing lung. 

Education and Training

PhD: University of Cincinnati College of Medicine, Cincinnati, Ohio, 1987.

Postdoctoral Fellowship: Division of Basic Science Research, Children's Hospital Research Foundation, Cincinnati, Ohio and Research Instructor, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 1987-1991.


View PubMed Publications