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Monica Malone McNeal, MS

Associate Director, Laboratory of Specialized Clinical Studies

Instructor, UC Department of Pediatrics

Phone: 513-636-7648

Fax: 513-636-0950

Email: monica.mcneal@cchmc.org

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Specialties

Clinical Interests

Vaccine development; rotavirus; influenza and CMV

Research Interests

Immunology of rotavirus infection

Biography

Monica Malone McNeal, MS, is a virologist in the Division of Infectious Diseases at Cincinnati Children’s Hospital Medical Center. She has more than 23 years of experience in rotavirus research. She has established an adult mouse model that has been used extensively in this facility and labs around the world. Her major expertise is in immunology and vaccine development. Currently she is the Associate Director of the Laboratory for Specialized Clinical Studies. This lab provides support for clinical studies involved in vaccine development. They perform work for several major pharmaceutical companies in addition to supporting other clinical researchers at Cincinnati Children’s.

Education and Training

MS: University of Cincinnati, Cincinnati, OH, 1981.

Publications

View PubMed Publications

Staat MA, Rice MA, Donauer S, Payne DC, Bresee JS, Mast TC, Curns AT, Cortese MM, Connelly B, McNeal M, Ward RL, Bernstein DI, Parashar UD, Salisbury S. Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methods. Pediatr Infect Dis J. 2010 Dec;29(12):1083-6.

Tan M, Huang P, Xia M, Fang PA, Zhong W, McNeal M, Wei C, Jiang W, Jiang X. Norovirus P particle, a novel platform for vaccine development and antibody production. J Virol. 2011 Jan;85(2):753-64.

Ward RL, McNeal MM. VP6: A candidate rotavirus vaccine. J Infect Dis. 2010 Sep 1;202 Suppl:S101-7. Review.

Bernstein DI, Farley N, Bravo FJ, Earwood J, McNeal M, Fairman J, Cardin R. The adjuvant CLDC increases protection of a herpes simplex type 2 glycoprotein D vaccine in guinea pigs. Vaccine. 2010 May 7;28(21):3748-53.

Bondoc AJ, Jafri MA, Donnelly B, Mohanty SK, McNeal MM, Ward RL, Tiao GM. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J Pediatr Surg. 2009 Aug;44(8):1479-90.

Ward RL, McNeal MM, Steele AD. Why does the world need another rotavirus vaccine? Ther Clin Risk Manag. 2008 Feb;4(1):49-63.

Jafri M, Donnelly B, Allen S, Bondoc A, McNeal M, Rennert PD, Weinreb PH, Ward R, Tiao G. Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia. Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G16-G26.

McNeal MM, Stone SC, Basu M, Clements JD, Choi AH, Ward RL. IFN-gamma is the only anti-rotavirus cytokine found after in vitro stimulation of memory CD4+ T cells from mice immunized with a chimeric VP6 protein. Viral Immunol. 2007 Dec;20(4):571-84.

Jafri M, Donnelly B, McNeal M, Ward R, Tiao G. MAPK signaling contributes to rotaviral-induced cholangiocyte injury and viral replication. Surgery. 2007 Aug;142(2):192-201.

Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, Caldwell C, Chougnet C, Bezerra JA. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology. 2007 Jul;133(1):268-77.