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Satish K. Madala, PhD

Research Instructor, Division of Pulmonary Medicine

Instructor, UC Department of Pediatrics

Phone: 513-636-9852

Email: satish.madala@cchmc.org

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Specialties

Pulmonary fibrosis; cystic fibrosis; scleroderma

Biography

Dr. Satish K Madala joined the Division of Pulmonary Medicine in 2011, after postdoctoral training in fibrotic disease research in the laboratory of Dr. Thomas A. Wynn, NIAID, NIH. Dr. Madala’s major research interests are to identify cellular and molecular mechanisms of human fibrotic diseases in particular idiopathic pulmonary fibrosis, cystic fibrosis and scleroderma. We use transgenic and non-transgenic mouse models to determine the molecular pathways that dictate pulmonary inflammation and fibrosis.

Education and Training

Postdoctoral training: Immunopathogenesis Section, LPD, NIAD, NIH, Bethesda, USA.

PhD: Osmania University, Hyderabad, India.

Publications

View PubMed Publications

Madala SK, Davidson CR, Schmidt SM, Ikegami M, Hardie WD. MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor activation. Am. J. Res. Cell Mol Biol. 2011 Oct:(in print).

Wynn TA, Barron L, Thompson RW, Madala SK, Wilson MS, Cheever AW, Ramalingam TR. Quantitative assessment of macrophage functions in repair and fibrosis. Curr Protoc Immunol. 2011 Apr; Chapter 14:Unit 14.22.

Madala SK, Maxfield MD, Davidson CR, Schmidt SM, Garry D, Ikegami M, Hardie WD, Glasser SW. Rapamycin regulates bleomycin-induced lung damage in SP-C deficient mice. Pulm Med. 2011.

Madala SK, Dolan M, Sharma D, Ramalingam TR, Wilson MS, Mentink-Kane MM, Thomas A. Wynn. Mapping mouse IL-13 binding regions using structure modeling, molecular docking and high-density peptide microarray analysis. Proteins. 2011 Jan;79(1):282-93.

Wilson MS, Ramalingam TR, Rivollier A, Shenderov K, Mentink-Kane MM, Madala SK, Cheever AW, Artis D, Kelsall BL, Wynn TA. Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity. Gastroenterology. 2011 Jan;140(1):254-64.

Németh K, Keane-Myers A, Brown J, Metcalfe D, Gorham J, Bundoc V,Madala SK, Hodges M, Karpati S, Mezey E . Bone marrow stromal cells use TGF-β to suppress allergic responses in a mouse model of ragweed-induced asthma. PNAS. 2010;107(12):5652-5657.

Wilson MS, Madala SK, Ramalingam TR, Thompson RW Mentink-Kane MM, Cheever AW, Thomas A. Wynn. Bleomycin and IL-1β-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med. 2010 Mar;207(3):535-52.

Madala SK, Pesce J, Ramalingam TR, Wilson MS, Thompson RW, Minnicozzi S, Mentink-Kane MM, Cheever AW, Thomas A. Wynn. Opposing roles for matrix metalloproteinases 12 and 13 in interleukin 13-dependent tissue remodeling during S. mansoni egg induced fibrosis. J Immunology. 2010;184(7):3955-3963.

Ramalingam TR, Pesce JT, Mentink-Kane MM, Madala SK, Cheever AW, Comeau MR, Ziegler SF, Thomas A. Wynn. Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin. J Immunology. 2009;182(10):6452-6459.

Grants

Role of TGFα-induced fibrocytes in pulmonary fibrosis and pulmonary hypertension. Principal Investigator. AHA NCRP Scientist Development Grant. Jan 2012- Dec 2015

Role of IL-31 in immunopathology of Systemic sclerosis (SSc). Principal Investigator. Bristol-Myers Squibb preclinical contract. 2011- 2013

Molecular Interventions for Pulmonary Fibrosis. Co-Principal Investigator. P50HL107159 (PI: Hardie). May 2011- April 2013.