Sean R. Moore, MD, MS

Division of Gastroenterology, Hepatology & Nutrition

Global Health Center

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email gina.dipuccio@cchmc.org

Clinical Interests

Pediatric gastroenterology

Research Interests

Undernutrition; diarrheal diseases; environmental enteropathy; intestinal stem cells

The Gastroenterology, Hepatology and Nutrition laboratory is broadly interested in the reciprocal cycle of childhood diarrhea and malnutrition, with a current focus on the mechanisms of a promising glutamine-based oral rehydration and nutrition therapy. Using cellular and molecular techniques in both cell culture and an infant mouse model of undernutrition, we study the role of EGFR -- a key regulator of intestinal homeostasis -- in glutamine’s benefits for intestinal health.

In addition, we participate in epidemiologic studies of early childhood diarrhea and undernutrition with colleagues at the Federal University of Ceará in Fortaleza, Brazil and the University of Virginia.
MS: Epidemiology, University of Virginia, Charlottesville, VA, 1998.

MD: Johns Hopkins University, Baltimore, MD, 2003.

Residency: Pediatrics, Vanderbilt University, Nashville, TN, 2006.

Fellowship: Pediatric Gastroenterology, Hepatology, & Nutrition, Vanderbilt University, Nashville, TN 2009.

Certification: Pediatrics, 2006; Gastroenterology, Hepatology, & Nutrition, 2013.

Moore SR, Pruszka J, Vallance J, Aihara E, Montrose M, Shroyer N, Hong C. Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine. Disease Models & Mechanisms. 2014;7:1123-1130.

Ueno PM, Oriá RB, Guedes M, de Azevedo, Willson T, Wu D, Hogan SP, Lima AA, Guerrant RL, Polk DB, Denson LA, Moore SR. Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition. American Journal of Physiology. 2011;301:G612-22.

Schlaudecker E, Steinhoff MC, Moore SR. Interactions of malnutrition, diarrhea, and pneumonia in childhood: Recent evidence from developing countries. Current Opinion in Infectious Diseases. 2011;24:1-7.

Moore SR, Lima AAM, Guerrant RL. Preventing 5 million child deaths from diarrhea in the next five years. Nature Reviews Gastroenterology & Hepatology. 2011;8:363-364.

Moore SR, NL Lima, Soares AM, Oriá RB, Pinkerton RC, Barrett LJ, Guerrant RL, Lima AA. Prolonged episodes of acute diarrhea reduce growth and increase risk of persistent diarrhea in children. Gastroenterology. 2010;39:1156-64.

Moore SR, Lorntz B, Lima AA, Guerrant RL. Risk factors for adverse outcomes in developing countries. Lancet. 2007;369:824-5.

Moore SR, Lima AA, Conaway MR, Schorling JB, Soares AM, Guerrant RL. Early childhood diarrhoea and helminthiases associate with long-term linear growth faltering. Int J Epidemiol. 2001;30:1457-64.

Moore SR, Lima AA, Schorling JB, Barboza MS, Jr., Soares AM, Guerrant RL. Changes over time in the epidemiology of diarrhea and malnutrition among children in an urban Brazilian shantytown, 1989 to 1996.Int J Infect Dis. 2000;4:179-86.

Lima AA, Moore SR, Barboza MS, Jr., Soares AM, Schleupner MA, Newman RD, Sears CL, Nataro JP, Fedorko DP, Wuhib T, Schorling JB, Guerrant RL. Persistent diarrhea signals a critical period of increased diarrhea burdens and nutritional shortfalls: a prospective cohort study among children in northeastern Brazil. J Infect Dis. 2000;181:1643-51.

Newman RD, Sears CL, Moore SR, Nataro JP, Wuhib T, Agnew DA, Guerrant RL, Lima AA. Longitudinal study of Cryptosporidium infection in children in northeastern Brazil. J Infect Dis. 1999;180:167-75.

Bad water, bad diet, bad stem cells: Epigenetic modeling of environmental enteropathy. Principal Investigator. The Bill & Melinda Gates Foundation Grand Challenges Explorations Phase II. Jul 2014 - Jun 2016.

Independent Scientist in Global Health Award: Mechanisms of alanyl-glutamine oral rehydration and nutrition therapy. Principal Investigator. Fogarty International Center/National Institutes of Health. Sep 2011 - Aug 2016.

Global and hepatobiliary-specific knockout of PIGR to generate environmental enteropathy in mice. Principal Investigator. The Bill & Melinda Gates Foundation. Aug 2013 - Aug 2015.

Network dynamics of rhythmic biological processes. Co-Principal Investigator. Defense Advanced Research Projects Agency. Jan 2012 - Dec 2015.

Metabonomic Biomarkers of Gut Function and Health: Modeling Enteropathy (EE) and Field Validation. Co-Investigator. The Bill & Melinda Gates Foundation. Nov 2012 - Apr 2015.