Biographies

Tesfaye B. Mersha, PhD

Assistant Professor, UC Department of Pediatrics

Phone: 513-803-2766

Fax: 513-636-1657

Email: tesfaye.mersha@cchmc.org

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Specialties

Clinical Interests

Allergy and allergy related disorders

Research Interests

Quantitative and statistical genetics and genomics; genetic linkage, association and admixture analysis; expression analysis; network and pathway analysis; gene ontology and functional commonalities analysis

Visit Dr Mersha's external lab website.

Visit Dr. Mersha's lab at Cincinnati Children's.

Biography

Tesfaye B. Mersha, PhD, is a quantitative geneticist. His background includes an early exposure to the many facets of biology and statistics and interested in cross-line disciplines to understand and solve complex genetic problems. During his post-doctoral fellowship program in statistical and human genetics, Dr. Mersha worked on statistical genetics methodologies and applied genetical data analysis to localize disease genes. Particularly, he focused on genetic analyses of metabolic and mental disorders using linkage, association and admixture mapping approach.

He developed genome-wide ancestry informative markers (AIMs) panel by mining databases including HapMap, Affymetrix and Illumina. The AIM markers are useful in ancestry inference, admixture mapping and structured association testing. He used over 4 million HapMap SNP data and developed approaches of chromosomal based finer population genetic structure characterization, localization of private SNPs and associated genes and pathways that could have pharmacogenomics implication.

In addition, Dr. Mersha is working on gene regulatory networks, gene ontology enrichment analysis and molecular profiling using various biologic and bioinformatic methodology for prioritizing asthma candidate genes. Dr. Mersha’s overall research interest and goal includes the use of population genomics, quantitative genetics, statistical genetics as well as proteomics and biological profiling and pathway methods to understand and dissect common complex diseases.

Education and Training

PhD: University of Göttingen, Germany, 2004.

MS: Alemaya University, Ethiopia, 1996.

BS: Alemaya University, Ethiopia, 1992.

Publications

View PubMed Publications

Grants

Admixture Mapping in African American Asthmatic Children. Principal Investigator. National Heart, Lung and Blood Institute. Jul 2010 - May 2015. #1K01HL103165.