Tesfaye B. Mersha, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-2766

Fax 513-636-1657

Email tesfaye.mersha@cchmc.org


Allergy and allergy related disorders


Quantitative and statistical genetics and genomics; genetic linkage, association and admixture analysis; expression analysis; network and pathway analysis; gene ontology and functional commonalities analysis

Visit Dr Mersha's external lab website.

Visit Dr. Mersha's lab at Cincinnati Children's.

Tesfaye B. Mersha, PhD, is a quantitative geneticist. His background includes an early exposure to the many facets of biology and statistics and interested in cross-line disciplines to understand and solve complex genetic problems. During his post-doctoral fellowship program in statistical and human genetics, Dr. Mersha worked on statistical genetics methodologies and applied genetical data analysis to localize disease genes. Particularly, he focused on genetic analyses of metabolic and mental disorders using linkage, association and admixture mapping approach.

He developed genome-wide ancestry informative markers (AIMs) panel by mining databases including HapMap, Affymetrix and Illumina. The AIM markers are useful in ancestry inference, admixture mapping and structured association testing. He used over 4 million HapMap SNP data and developed approaches of chromosomal based finer population genetic structure characterization, localization of private SNPs and associated genes and pathways that could have pharmacogenomics implication.

In addition, Dr. Mersha is working on gene regulatory networks, gene ontology enrichment analysis and molecular profiling using various biologic and bioinformatic methodology for prioritizing asthma candidate genes. Dr. Mersha’s overall research interest and goal includes the use of population genomics, quantitative genetics, statistical genetics as well as proteomics and biological profiling and pathway methods to understand and dissect common complex diseases.

BS: Alemaya University, Ethiopia, 1992.

MS: Alemaya University, Ethiopia, 1996.

PhD: University of Göttingen, Germany, 2004.

View PubMed Publications

Mersha TB, Martin LJ, Biagini Myers JM, Kovacic MB, He H, Lindsey M, Sivaprasad U, Chen W, Khurana Hershey GK. Genomic Architecture of Asthma Differs by Sex. Genomics. 2015 Mar 25.

Mersha TB, Abebe T. Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities. Hum Genomics. 2015 Jan 7;9(1):1.

Sadhasivam S, Zhang X, Chidambaran V, Mavi J, Pilipenko V, Mersha TB, Meller J, Kaufman KM, Martin LJ, McAuliffe J. Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects. Pharmacogenomics J. 2015 Jan 6.

Fardo DW, Zhang X, Ding L, He H, Kurowski B, Alexander ES, Mersha TB, Pilipenko V, Kottyan L, Nandakumar K, Martin L. On family-based genome-wide association studies with large pedigrees: observations and recommendations. BMC Proc. 2014 Jun 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S26.

Pilipenko VV, He H, Kurowski BG, Alexander ES, Zhang X, Ding L, Mersha TB, Kottyan L, Fardo DW, Martin LJ. Using Mendelian inheritance errors as quality control criteria in whole genome sequencing data set. BMC Proc. 2014 Jun 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S21.

Ding L, Kurowski BG, He H, Alexander ES, Mersha TB, Fardo DW, Zhang X, Pilipenko VV, Kottyan L, Martin LJ. Modeling of multivariate longitudinal phenotypes in family genetic studies with Bayesian multiplicity adjustment. BMC Proc. 2014 Jun 17;8(Suppl 1):S69.

Biagini Myers JM, Martin LJ, Butsch Kovacic M, Mersha TB, He H, Pilipenko V, Lindsey MA, Ericksen MB, Bernstein DI, LeMasters GK, Lockey JE, Khurana Hershey GK. Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma. J Allergy Clin Immunol. 2014 Oct;134(4):891-899.e3.

Ding L, Abebe T, Beyene J, Wilke RA, Goldberg A, Woo JG, Martin LJ, Rothenberg ME, Rao M, Hershey GK, Chakraborty R, Mersha TB. 2013. Rank-based genome-wide analysis reveals the association of Ryanodine receptor-2 gene variants with childhood asthma among human populations. Hum Genomics. 2013 Jul 5;7:16.