Tesfaye B. Mersha, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-2766

Fax 513-636-1657

Email tesfaye.mersha@cchmc.org

Clinical Interests

Allergy and allergy related disorders

Research Interests

Quantitative and statistical genetics and genomics; genetic linkage, association and admixture analysis; expression analysis; network and pathway analysis; gene ontology and functional commonalities analysis

Visit Dr Mersha's external lab website.

Visit Dr. Mersha's lab at Cincinnati Children's.

Tesfaye B. Mersha, PhD, is a quantitative geneticist. His background includes an early exposure to the many facets of biology and statistics and interested in cross-line disciplines to understand and solve complex genetic problems. During his post-doctoral fellowship program in statistical and human genetics, Dr. Mersha worked on statistical genetics methodologies and applied genetical data analysis to localize disease genes. Particularly, he focused on genetic analyses of metabolic and mental disorders using linkage, association and admixture mapping approach.

He developed genome-wide ancestry informative markers (AIMs) panel by mining databases including HapMap, Affymetrix and Illumina. The AIM markers are useful in ancestry inference, admixture mapping and structured association testing. He used over 4 million HapMap SNP data and developed approaches of chromosomal based finer population genetic structure characterization, localization of private SNPs and associated genes and pathways that could have pharmacogenomics implication.

In addition, Dr. Mersha is working on gene regulatory networks, gene ontology enrichment analysis and molecular profiling using various biologic and bioinformatic methodology for prioritizing asthma candidate genes. Dr. Mersha’s overall research interest and goal includes the use of population genomics, quantitative genetics, statistical genetics as well as proteomics and biological profiling and pathway methods to understand and dissect common complex diseases.

PhD: University of Göttingen, Germany, 2004.

MS: Alemaya University, Ethiopia, 1996.

BS: Alemaya University, Ethiopia, 1992.

Ding L, Abebe T, Beyene J, Wilke RA, Goldberg A, Woo JG, Martin LJ, Rothenberg ME, Rao M, Hershey GK, Chakraborty R, Mersha TB. Rank-based genome-wide analysis reveals the association of Ryanodine receptor-2 gene variants with childhood asthma among human populations. Hum Genomics. 2013 Jul 5;7:16.

Amirisetty S, Hershey GK, Baye TM. AncestrySNPminer: a bioinformatics tool to retrieve and develop ancestry informative SNP panels. Genomics. 2012 Jul;100(1):57-63.

Baye TM, He H, Ding L, Kurowski BG, Zhang X, Martin LJ. Population structure analysis using rare and common functional variants. BMC Proc. 2011 Nov 29;5 Suppl 9:S8.

Baye TM, Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenberg ME, Wills-Karp M, Eissa NT, Borish L, Hershey, GKK. Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children. PLoS One. 2011 Feb 28;6(2): e16522.

Ding L, Wiener H, Abebe T, Altaye M, Go RC, Kercsmar C, Martin L., Khurana Hershey GK, Chakorborty R, Baye TM. Comparison of measures of marker informativeness for ancestry and admixture mapping. BMC Genomics. 2011 Dec 20;12:622.

Baye TM, Abebe T, Wilke RA. Genotype-environment interaction and its translational implications. Per Med. 2011 Jan;8(1):59-70.

Baye TM. Inter-chromosomal variation in the pattern of human population genetic structure. Hum Genomics. 2011May;5(4):220-240.

Baye TM, Wilke RA. Mapping genes that predict treatment outcome in admixed populations. Pharmacogenomics J. 2010 Dec;10(6):465-77.

Baye TM, Martin LJ, Khurana Hershey GK. Application of genetic/genomic approaches to allergic disorders. J Allergy Clin Immunol. 2010 Sep;126(3):425-36.

Baye TM, Wilke RA, Olivier M. Genomic and geographic distribution of private SNPs and pathways in human populations. Per Med. 2009 Nov 1; 6(6):623-641.

Admixture Mapping in African American Asthmatic Children. Principal Investigator. National Heart, Lung and Blood Institute. Jul 2010 - May 2015. #1K01HL103165.