Satoshi H. Namekawa, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-1377

Fax 513-803-1160

Email satoshi.namekawa@cchmc.org

The long-term goal of my research is to understand the mechanisms and evolution of epigenetic events during mammalian reproduction. One of our focus areas is epigenetic regulation of sex chromosomes in germ cell development. Recently, my laboratory demonstrated that DNA damage response pathways trigger epigenetic programming on the sex chromosomes in germ cells. An on-going direction of my laboratory is to pursue a general link between DNA damage response pathways and epigenetic programming. Another goal of my laboratory is to identify novel factors and related pathways that control epigenetic programming during mouse reproduction, especially focusing on the events occurring on sex chromosomes during spermatogenesis as well as the regulatory mechanisms in germline stem cells.

Visit the Namekawa Lab.

Dr. Namekawa received his PhD from Tokyo University of Science in 2005. He completed postdoctoral training in the laboratory of Dr. Jeannie T. Lee at Massachusetts General Hospital and Harvard Medical School in 2009, followed by his faculty appointment at Cincinnati Children's in 2009. He is funded by NIH R01 Award and the Basil O’Connor Award from March of Dimes Foundation.

PhD: Tokyo University of Science, Japan, 2005.

BS: Tokyo University of Science, Japan, 2000.

View PubMed Publications

Hasegawa, K., Sin, H. S., Maezawa, S., Broering, T.J., Kartashov, A. V., Alavattam, K.G., Ichijima, Y., Zhang, F., Bacon, W.C., Greis, K.D., Andreassen, P.R., Barski, A., and Namekawa S.H. SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitinationDev Cell. Accepted. 2015. 

Broering TJ*, Alavattam KG*, Sadreyev RI, Ichijima Y, Kato Y, Hasegawa K, Camerini-Otero RD, Lee JT, Andreassen PR, Namekawa SH. BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis. (*equal contribution) J Cell Biol. 2014 Jun 9;205(5):663-75.

Namekawa SH. Slide preparation method to preserve three-dimensional chromatin architecture of testicular germ cells. J Vis Exp. 2014 Jan 10;(83).

Sin HS, Namekawa SH. The great escape: active genes on inactive sex chromosomes and their evolutionary implications. Epigenetics. 2013 Sep;8(9):887-92.

Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH. RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in postmeiotic spermatids. Genes Dev. 2012 Dec 15:26(24)2737-2748.

Ichijima Y, Sin HS, Namekawa SH. Sex chromosome inactivation in germ cells: Emerging roles of DNA damage response pathways. Cell Mol Life. Sci. 2012Aug;69(15):2559-72.

Sin HS, Ichijima Y, Koh E, Namiki M, Namekawa SH. Human post meiotic sex chromatin and its impact on sex chromosome evolution. Genome Res. 2012 May;22(5):827-36.

Payer B, Lee JT, Namekawa SH. X-inactivation and X-reactivation: Epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Hum Genet. 2011Aug;130(2):265-80.

Ichijima, Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev.2011 May 1;25(9):959-71.

Namekawa SH, Lee JT. Detection of nascent RNA, single-copy DNA, and protein localization by immunoFISH in murine germ cells and pre-implantation embryos. Nature Protocols. 2011 Feb;6(3):270-84.