Clinical Interests

Leukemia; lymphoma

Research Interests

Molecular etiology of pediatric leukemias, especially in children with Down syndrome; novel therapeutics for relapsed and high-risk leukemia and lymphoma

MD: Harvard Medical School, Boston, MA, 2000.

Residency: Boston Combined Residency Program, Boston Children's Hospital and Boston Medical Center, Boston, MA, 2003.

Fellowship: Stanford University School of Medicine, Stanford, CA, 2007.

MS: Stanford University, Stanford, CA, 2008.

Certification: Pediatrics, 2003; Pediatric Hematology/Oncology, 2009.

Spicakova T, O'Brien MM, Duran GE, Sweet-Cordero A, Sikic BI. Expression and silencing of the microtubule-associated protein Tau in breast cancer cells. Mol Cancer Ther. 2010 Nov;9(11):2970-81.

O'Brien MM, Lacayo NJ, Lum BL, Kshirsagar S, Buck S, Ravindranath Y, Bernstein M, Weinstein H, Chang MN, Arceci RJ, Sikic BI, Dahl GV. Phase I study of valspodar (PSC-833) with mitoxantrone and etoposide in refractory and relapsed pediatric acute leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2010 May;54(5):694-702.

O'Brien MM, Donaldson SS, Balise RR, Whittemore AS, Link MP. Second malignant neoplasms in survivors of pediatric Hodgkin's lymphoma treated with low-dose radiation and chemotherapy. J Clin Oncol. 2010 Mar 1;28(7):1232-9.   

Jeng MR, O’Brien M, Wong W, Zoland J, Lea J, Tang N, Glader B.  Monthly recombinant tissue plasminogen activator administration to implantable central venous access devices decreases infections in children with haemophilia. Haemophilia. 2009 Nov 15(6):1272-80.

Donaldson SS, O'Brien MM. Understanding the risk of second malignant tumors in children with Hodgkin's disease. Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):4-5.

O’Brien MM, Lee-Kim Y, George T, McClain K, Twist C, Jeng M.   Precursor B-cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis: case series and review of the literature.  Pediatr Blood Cancer. 2008 Feb 50(2):381-3

O’Brien MM, Taub JW, Chang MN, Massey GV, Stine KC, Raimondi SC, Becton D, Ravindranath Y, Dahl GV.  Cardiomyopathy in children with Down syndrome treated for acute myeloid leukemia: a report from the Children’s Oncology Group Study POG 9421.  J Clin Oncol. 2008 Jan 26(3):414-420.