Anne Karina T. Perl, MS, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-636-6084

Fax 513-636-7868

Email anne.perl@cchmc.org

Lung development and lung regeneration

Visit the Perl Lab.

PhD: University of Vienna, Austria, 1998.

Chen L, Acciani T, Le Cras T, Lutzko C, Perl AK. Dynamic Regulation of Platelet-Derived Growth Factor Receptor α Expression in Alveolar fibroblasts During Realveolarization. Am J Respir Cell Mol Biol. May 31, 2012.

Rawlins EL, Perl AK. The a"MAZE"ing world of lung-specific transgenic mice. Am J Respir Cell Mol Biol. 2012 Mar;46(3):269-82. Epub 2011 Dec 28.

Perl AK, Riethmacher D, Whitsett JA. Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis. Am J Respir Crit Care Med. 2011 Feb 15;183(4):511-21.

Perl AK, Gale E. FGF signaling is required for myofibroblast differentiation during alveolar regeneration. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L299-308.

Lin S, Perl AK, Shannon JM. Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. J Biol Chem. 2006 Jun 16;281(24):16716-26.

Martis PC, Whitsett JA, Xu Y, Perl AK, Wan H, Ikegami M. C/EBPalpha is required for lung maturation at birth. Development. 2006 Mar;133(6):1155-64.

Perl AK, Wert SE, Loudy DE, Shan Z, Blair PA, Whitsett JA. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol. 2005 Nov;33(5):455-62.

Perl AK, Kist R, Shan Z, Scherer G, Whitsett JA. Normal lung development and function after Sox9 inactivation in the respiratory epithelium. Genesis. 2005 Jan;41(1):23-32.

Miller LA, Wert SE, Clark JC, Xu Y, Perl AK, Whitsett JA. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn. 2004 Sep;231(1):57-71.

Hokuto I, Ikegami M, Yoshida M, Takeda K, Akira S, Perl AK, Hull WM, Wert SE, Whitsett JA. Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest. 2004 Jan;113(1):28-37.

Airway Progenitor Cell Proliferation and Differentiation During Lung Repair. Co-investigator. National Institutes of Health/National Heart, Lung and Blood Institute. Dec 2011 - Nov 2016. U01 HL110964.