Dao Pan, PhD

Associate Professor, UC Department of Pediatrics

Phone 513-636-6315

Fax 513-636-1330

Email Dao.Pan@cchmc.org

Clinical

Hematopoietic stem cells; mesenchymal stem/progenitor cells; gene therapy; human genetics; translational research; lysosomal storage diseases

BS: Peking Normal University, Beijing, China, 1988.

MS: Peking Normal University, Beijing, China, 1991.

PhD: University of Minnesota, Minneapolis, MN, 1997.

View PubMed Publications

Wang X, Chiang A, Shin SC, Chen L, Pan D, Rawlings DJ, Miao CH. Intraosseous delivery of lentiviral vectors targeting factor VIII expression in platelets corrects murine Hemophilia AMol Ther. 2015 Feb 6;23(4):617-26.

El-Amouri SS, Dai D, Han JF, Brady RO, Pan D. Normalization and improvement of CNS deficits of mice with Hurler syndrome after long-term peripheral delivery of BBB-targeted Iduronidase. Mol Ther. 2014;22(12):2028-37.

Dai M, Han J, El-Amouri SS, Brady RO, Pan D. Platelets are efficient and protective depots for storage, distribution and delivery of lysosomal enzyme in mice with Hurler Syndrome. Proc Natl Acad Sci USA. 2014;111:2680-2685.

Wang D, El-Amouri SS, Dai M, Kuan A, Hui D, Brady RO, Pan D. Engineering a lysosomal enzyme with receptor-binding domain of ApoE enables delivery across the blood-brain barrier. Proc Natl Acad Sci U S A. 2013;110:2999-3004.  

El-Amouri SS, Cao P, Miao CH, Pan D. Secreted luciferase for in vivo evaluation of systemic protein delivery in mice. Mol Biotech. 2013;53:63-73.

Pan D*, Kalfa TA, Wang D, Risinger M, Crable S, Ottlinger A, Mount DB, Hubner CA, Franco RS, Joiner CH*. KCl cotransporter gene expression during human and murine erythroid differentiation. J Biol Chem. 2011;286(35): 30492-30503. *co-correspondent authors.

Wang D, Zhang W, Kalfa TA, Grabowski G, Davies S, Malik P, Pan D. Reprogramming Erythroid Cells for Lysosomal Enzyme Production Leads to Visceral and CNS Cross-correction in Mice with Hurler Syndrome. Proc Natl Acad Sci U S A. 2009;106:19958-63.

Worsham N, Scheusler T, von Kalle C, Pan D. In vivo gene transfer into adult stem cells in non-conditioned mice by in situ delivery of a lentiviral vector. Mol Ther. 2006;14(4): 514-524.

Gaucher Disease: Treatment of Neurodegenerative Disease. Principal Investigator. National Institute of Neurological Disorders and Stroke. Sep 2013-May 2018. #R01 NS086134.