A photo of Dr. Perentesis.

John P. Perentesis, MD, FAAP

Director, Division of Oncology and Cancer Programs

Deb Kleisinger Endowed Chair of Novel Cancer Treatments

Executive Co-Director, Cancer and Blood Diseases Institute

Director, Leukemia / Lymphoma Program

Cincinnati Children's Principal Investigator, Children’s Oncology Group (COG)

Cincinnati Children's Principal Investigator, National Cancer Institute Pediatric Phase 1 Consortium

Professor, UC Department of Pediatrics

Phone: 513-636-8241


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Clinical Interests

Acute myeloid leukemia; neuroblastoma; PNET / Ewing's sarcoma and osteosarcoma; new anticancer drug development; Phase I clinical trials

Research Interests

Molecular etiology and pharmacogenetics of pediatric cancers; Down syndrome-associated leukemia; new anticancer drug development


John P. Perentesis, MD, is a nationally recognized expert in the development of new drugs and molecular therapies for pediatric and young adult cancers and leukemia. His laboratory has developed novel anticancer drugs, and discovered genes important in the growth of normal and malignant cells. His laboratory is also developing the use of tumor and patients genetics research for personalizing therapies. In clinical research, he serves in leadership roles for the National Cancer Institute’s Investigational Drug Steering Committee and the NCI Pediatric Phase I Consortium.

In 2010, Dr. Perentesis was elected by pediatric oncologists from across the country to the national Executive Committee for the NCI-funded Children’s Oncology Group (COG). The COG is the world's largest, cooperative children's cancer research entity. He also is in leadership efforts in the COG for new therapies for leukemia, and adolescent and young adult cancers.

Education and Training

MD: University of Michigan, Ann Arbor, MI, 1980.

Residency: University of Minnesota Medical School, Minneapolis, MN, 1983.

Fellowship: University of Minnesota Medical School, Minneapolis, MN, 1986.

Postdoctoral: University of Minnesota Medical School, Minneapolis, MN, 1986.

Certification: Pediatrics, 1989; Hematology/Oncology, 1990.


View PubMed Publications


The Children's Oncology Group Chair Grant. Site Principal Investigator. National Institutes of Health. Mar 2008 - Mar 2013. #U10 CA 098543.

Children's Oncology Group Phase I. Site Principal Investigator. National Institutes of Health. Aug 2002 - Jul 2012. #U01 CA 097452.

Children's Oncology Group New Publication Committee. National Institutes of Health. Sep 2006 - Jul 2012. #U01 CA 97542 .

Cincinnati Children's Hyundai Scholar in Childhood Cancer Drug Development. Hyundai Hope on Wheels. Oct 2010 - Oct 2011.