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Joo-Seop Park, PhD

Assistant Professor, Division of Pediatric Surgery

Phone: 513-803-7871

Email: joo-seop.park@cchmc.org

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Specialties

Molecular biology; genetics

Biography

Joo-Seop Park, PhD is an assistant professor in the Divisions of Pediatric Urology and Developmental Biology at Cincinnati Children's Hospital Medical Center. He received his bachelor's in pharmacy from Seoul National University in Seoul, South Korea. He subsequently studied the regulation of gene transcription with Dr. Jeffrey W. Roberts at Cornell University in Ithaca, NY where he obtained his doctorate in Molecular Biology and Genetics in 2004. Dr. Park then went on to postdoctoral training with Dr. Andrew P. McMahon at Harvard University where he was awarded fellowships from the National Kidney Foundation and the Charles King Trust to study mammalian kidney development.

Dr. Park is interested in understanding how progenitor cells maintain their multi-potent status and how they differentiate into different types of cells during organogenesis of the mammalian kidney and bladder. His lab studies transcriptional and epigenetic controls of cis-regulatory modules that act downstream of various signaling pathways.

Education and Training

PhD: Molecular Biology, Cornell University.

Publications

View PubMed Publications.

Park J-S*, Ma W, O’Brien LL, Chung E, Guo J-J, Cheng J-G, Valerius MT, McMahon JA, Wong WH, McMahon AP*. Six2 and Wnt regulate self-renewal and commitment of nephron progenitors throughshared gene regulatory networks. Developmental Cell. 2012;23:637-651 (*co-corresponding authors)

Park JS, Valerius MT, McMahon AP. Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development. 2007 Jul;134(13):2533-9.

Park JS, Roberts JW. Role of DNA bubble rewinding in enzymatic transcription termination. Proc Natl Acad Sci USA. 2006 Mar 28;103(13):4870-5.

Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Developmental Cell.2005 Aug;9(2):283-92.

Roberts J, Park JS. Mfd, the bacterial transcription repair coupling factor: translocation, repair and termination.Curr Opin Microbiol. 2004 Apr;7(2):120-5.

Park JS, Marr MT, Roberts JW. E. coli Transcription repair coupling factor (Mfd protein) rescues arrested complexes by promoting forward translocation. Cell. 2002 Jun 14;109(6):757-67.

Lee YH, Park JS, Park CH, Lee SK. Synergistic effect of cyclic AMP and insulin on the expression of cyclin A gene in Swiss 3T3 cells.Biochem Biophys Res Commun. 1998 Mar 27;244(3):843-8.