Manoj K. Pandey, PhD

Instructor, UC Department of Pediatrics

Phone 513-803-1694

Email manoj.pandey@cchmc.org

Clinical

Immunology

Research

Lipid arbitrated antibodies and cytokines comebacks in several Lysosomal diseases.

Manoj Kumar Pandey is a scientist in the Division of Human Genetics at Cincinnati Children's Hospital and Medical Research Center. Dr. Pandey earned his PhD in the topic “Maternal Immunoregulation and Fetal Survival” from the Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, India. He completed his Post-Doctoral Trainings from Mayo Clinic, Rochester, MN and Cincinnati Children’s Hospital and Medical Research Center, Cincinnati, OH. Dr. Pandey has presented and published his research outcomes in various national and international sessions and reputed peer-reviewed medical and scientific journals. He is a member of the American Association of Immunology, the American Association for the Advancement of Science, the International Society of Complement and the Mayo Clinic Alumni Association. The mainstream of Dr. Pandey’s research is based on the characterization of various immunological cells as well as their effector functions for persuading inflammation in illnesses like immune complex mediated diseases, asthma, cancer, recurrent spontaneous abortion and Gaucher diseases.

MS: CSJM University, India, 1995.

PhD: Sanjay Gandhi Post Graduate Institute of Medical Sciences, India, 2003.

Post Doc: Mayo Clinic, Rochester, MN, 2004.

Post Doc: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2008.

Iankov ID*, Pandey MK*, Harvey M, Griesmann GE, Federspiel MJ, Russell SJ. Immunoglobulin g antibody-mediated enhancement of measles virus infection can bypass the protective antiviral immune response. J Virol 2006, 80 (17):8530-8540. *shared first authorship.

Kohl J, Balder R, Lewkowish I, Pandey MK, Hawlisch H, Wang L, Herman N, Best J, Zwirner J, Whitsett JA, Lambns JD, Paul R, Schmitz-Perreira S, Scharfstein J, Wills-Karp M.A. Regulatory role for the C5a anaphylatoxin on type 2 immunity in asthma. J Clin Invest 2006, 16 (3):783-796.

Jongerius I, Köhl J, Pandey MK, Ruyken M, Van Kessel KPM, Van Strijp JAG, Rooijakkers SHM. Staphylococcal complement evasion by various convertase-blocking molecules. J Exp Med 2007, 204(10): 2461-2471.

Bestebroer J, Aerts PC, Rooijakkers SH, Pandey MK, Köhl J, van Strijp JA, de Haas CJ. Functional basis for complement evasion by staphylococcal superantigen-like7. Cell Microbiol 2010, 12(10): 1506–1516.

Pandey MK, Rani R, Zhang W, Setchell K, Grabowski GA. Immunological cell type characterization and Th1-Th17 cytokine production in a mouse model of Gaucher disease. Mol Genet Metab 2012, 106:310-322.

Karsten CM*, Pandey MK*, Figge J, Taylor PR, McDonald JU, Strait RT, Harris NL, Koehl G, Brown GD, Finkelman FD, Koehl J. Galactosylated IgG1 links FcγRIIB and Dectin-1 to block complement-mediated inflammation. Nat Med 2012,18(9):1401-1406. *shared first authorship.

Pandey, MK., Grabowski GA. Immunological cells and functions in Gaucher disease. Crit Revi Onco 2013, 18(3): 197–220.

Stemerding AM, Köhl J, Pandey MK, Kuipers A, Leusen JH, Boross P, Nederend M, Vidarsson G, Weersink AY, van de Winkel JG, van Kessel KP, van Strijp JA. Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcγR antagonists that inhibit IgG-mediated effector functions. J Immunol 2013; 191(1): 353-362.

Pandey MK. Molecular Basis for Downregulation of C5a-Mediated Inflammation by IgG1 Immune Complexes in Allergy and Asthma. Curr Allergy Asthma Rep 2013; 2013(6): 596-606.

Pandey MK, Nicholas JA, Xu Y, Zhang W, Setchell K, Grabowski GA. Gaucher Disease: Chemotactic factors and immunological cell invasion in a mouse model. Mol Genet Metab 2014, 111(2): 163-171.