Qishen Pang, PhD

Professor, UC Department of Pediatrics

Phone 513-636-1152

Fax 513-636-3768

Email qishen.pang@cchmc.org

Signal transduction in Fanconi anemia and its evolution to leukemia.

Visit the Pang Lab.

PhD: Oregon State University, Corvallis, Oregon, 1993.

Postdoctoral Fellow: Oregon Health Sciences University, Portland, OR, 2000.

Du W, Amarachintha S., Sipple J, Schick J., Steinbrecher K. and Pang Q. Inflammation-mediated Notch signaling skews Fanconi anemia hematopoietic stem cell differentiation. J. Immunol., 2013 Sep 1;191(5):2806-17.Aug 7. [Epub ahead of print].

Guo F, Li  J, Zhang S, Du W, Sipple J, Phelan J, Grimes HL,  Zheng Y, and Pang Q. mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression. Leukemia. 2013 Jul 15. [Epub ahead of print].

Du W, Erden O, Pang Q. TNF-α signaling in Fanconi anemia. Blood Cells Mol Dis. 2013 Jul 24. [Epub ahead of print]

Guo F, Li J, Du W, Zhang S, O'Connor M, Thomas G, Kozma S, Zingarelli B, Pang Q, Zheng Y. (2013) mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells.Leukemia. 2013 Mar 29. [Epub ahead of print]. PMID:23538752

Shen C, Oswald D, Phelps D, Cam H, Pelloski CE, Pang Q, Houghton PJ. (2013) Regulation of FANCD2 by the mTOR Pathway Contributes to the Resistance of Cancer Cells to DNA Double-Strand Breaks.Cancer Res. 73(11):3393-401.

Guo F, Zhang S, Grogg M, Cancelas JA, Varney ME, Starczynowski DT, Du W, Yang JQ, Liu W, Zhu W, Thomas G, Kozma S, Pang Q, Zheng Y. Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica. 2013 Sep;98(9):1353-8.May 28. [Epub ahead of print]

Li X, Sipple J, Pang Q, and Du W. Salidroside stimulates DNA repair enzyme Parp-1 activity in HSC maintenance. Blood. 119, 4162-4173. 2012.

Du W, Rani R, Sipple J, Schick J, Myers KC, Mehta P, Andreassen PA, Davies SM, and Pang Q. The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters. Blood. 119(18):4142-51. 2012.

Ali AM, Pradhan A, Singh TR, Du C, Li J, Wahengbam K, Grassman E, Auerbach AD, Pang Q, Meetei AR. FAAP20: a novel ubiquitin-binding FA nuclear core complex protein required for functional integrity of the FA-BRCA DNA repair pathway.Blood. 119(14):3285-94. 2012.

Li J, Sipple J, Maynard S, Mehta PA, Rose SR, Davies SM, Pang Q. Fanconi Anemia Links Reactive Oxygen Species to Insulin Resistance and Obesity.Antioxid Redox Signal. 17(8):1083-98. 2012.

Role of tumor necrosis factor in leukemogenesis. Leukemia and Lymphoma Society. July 2008 - Jun 2013.

Role of FA proteins in hematopoiesis. National Institutes of Health. May 2005 - Apr 2015. 

Targeted improvement in stem cell therapy for leukemia and bone marrow failure syndromes. National Institutes of Health. Feb 2011 - Jan 2016.