A photo of Damien Reynaud.

Damien Reynaud, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-4498

Email damien.reynaud@cchmc.org

Hematopoietic stem and progenitor cells; mechanisms of leukemic progression B cell development

Dr. Reynaud’s long-standing research interest is to understand the mechanisms controlling cell fate decisions in the hematopoietic system. During his graduate and post-graduate training, he worked to decipher the transcriptional regulatory networks that (i) control self-renewal activity and lineage specification in hematopoietic stem cells and (ii) regulate progenitor differentiation during the establishment of the natural and adaptive immune system. More recently he investigated the deregulation in stem and progenitor cell activity that, in adults, leads to the development of abnormal hematopoiesis and eventually to chronic myeloid leukemia. This work uncovered an unexpected contribution of the pro-inflammatory environment to leukemia development. Notably he identified a novel function for the pro-inflammatory cytokine IL-6 in reprogramming the fate of an early leukemic progenitor by promoting myeloid development at the expense of lymphoid differentiation. Following this work, the overall goal of his research at Cincinnati Children’s Hospital Medical center is to characterize how micro-environmental signals regulate normal B lymphoid and how corruption of these signals contribute to the initiation, maintenance and progression of acute lymphoblastic leukemia.

PhD: University Renee Descartes, Paris, France, 2004.

Postdoctoral Fellow: University of Chicago/HHMI, Chicago, IL, 2008; University of California, San Francisco, San Francisco, CA, 2013.

Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21;494(7437):323-7.

Reynaud D*, Pietras EM, Barry-Holson K, Mir A, Binnewies M, Jeanne M, Sala-Torra O, Radich JP, Passegué E*. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell. 2011 Nov 15;20(5): 661-673. (*co-corresponding authors).

Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. Regulation of B cell fate commitment and VH gene rearrangements by Ikaros. Nature Immunology. 2008 Aug; 9(8): 927-36.

Reynaud D*, Ravet E*, Titeux M, Mazurier F, Renia L, Dubart-Kupperschmitt A, Romeo PH, Pflumio F. SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment. Blood. 2005 Oct 1;106(7): 2318-28. (*co-first author).

Ravet E*, Reynaud D*, Titeux M, Izac B, Fichelson S, Romeo PH, Dubart-Kupperschmitt A, Pflumio F. Characterization of DNA-binding dependent and independent functions of SCL/TAL1 during human erythropoiesis. Blood. 2004 May 1; 103(9): 3326-35. (*co-first author).

Reynaud D, Lefort N, Manie E, Coulombel L, Levy Y. In vitro identification of human Pro-B cells which give rise to macrophages, NK and T cells. Blood. 2003 Jun 1; 101(11): 4313-21.