Biographies

Nancy Ratner, PhD

Beatrice C. Lampkin Chair, Cancer Biology

Professor, UC Department of Pediatrics

Phone: 513-636-9469

Fax: 513-636-3549

Email: nancy.ratner@cchmc.org

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Specialties

Clinical Interests

Development of the nervous system; peripheral nerve tumor formation

Research Interests

Genetic mutations in tumor suppressor genes

Visit the Ratner Lab.

Biography

Dr. Nancy Ratner PhD,  is interested in understanding mechanisms of peripheral nerve tumor (neurofibroma) formation in Neurofibromatosis type 1 (NF1), a common inherited disorder in which children are predisposed to cancer of the nervous system, to learning problems, bone disorders, and other cancers. She identified EGFR as a potential therapeutic target in NF1 peripheral nerve tumorigenesis, and has developed cell culture and mouse models of NF1 nerve tumorigenesis. Her laboratory has also used analysis of gene expression to identify critical genes in neurofibroma and their malignant derivatives, MPNST. 

Dr. Ratner received her bachelor's from Brown University, her doctorate from Indiana University, and was a postdoctoral fellow at Washington University in St. Louis. She was a member of the faculty at the University of Cincinnati from 1987 -  2004. Dr. Ratner is currently a professor in the Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati, and the program leader for Cancer Biology and Neural Tumors Program in the Cancer and Blood Disorders Institute where she holds the Beatrice C. Lampkin Endowed Chair in Cancer Biology and serves as PI of the NINDS P50 “Cincinnati Center in NF Research”. 

Dr. Ratner is an active member of the International Consortium on the Molecular Biology of NF1, NF2, and schwannomatosis and was a member of the advisory board for the National Neurofibromatosis Foundation (now Children’s Tumor Foundation) from 1989 – 2007. She chaired the Department of Defense Neurofibromatosis Research Program Integration Panel in 2008, and currently serves as a member of the James McDonnell Brain Tumor Research Advisory Board. She received the von Recklinghausen Award from the Children’s Tumor Foundation in 2010.

Education and Training

PhD: Indiana University, 1982.

BA: Brown University, 1975.

Fellowship: Washington University St. Louis, 1982-1987.

Publications

View PubMed Publications

Grants

NIH-R01 NS 28840-20, "Mitogenic Activities in Neurofibromatosis", 9/2011 - 9/2016 (Ratner, PI)

NIH-R01 CA118032-04, "Schwann cells in Neurofibromatosis type 2", 7/2007 - 6/2012 (Ratner, PI)

NIH-P50-NS057531-03, "Cincinnati Center for Neurofibromatosis Research", 7/2008 - 6/2013 (Ratner, PI)

Children's Tumor Foundation, "Preclinical Testing of Neurofibroma and MPNST", 7/2009 - 6/2011 (Cripe, PI, Ratner, Co-PI)

U.S. Army NF Program, NF080052, "Therapeutic Targets for Peripheral Nerve Tumors: NF1, NF2, and Schwannomatosis", 3/2009 - 9/2011 (Ratner, PI) 

U.S. Army NF Program, DOD W81XWH-10-1-0116,  "Modeling the Brain in NF1", 4/2010 - 3/2013 (Ratner, PI)