Biographies

E-mail this page

(All fields required)

Recipient's email address

Please enter a valid email.

Your name

Please enter your name.

Your email address

Please enter a valid email.

Find another Doctor or Researcher

High Res

Sudarsan Rajan, PhD

Assistant Professor, UC Department of Pediatrics

Phone: 513-803-7860

Email: sudarsan.rajan@cchmc.org

Show All

Specialties

Development of humanized mouse models for cardiovascular research and understanding the intracellular signaling pathways; contractile and regulatory protein gene expression and function

Biography

Sudarsan Rajan, PhD, received his doctorate in India and the post-doctoral training in the Department of Molecular Genetics, University of Cincinnati. His expertise has been in development of humanized mouse models for cardiovascular research with special focus on contractile and regulatory proteins. He was selected as one of the three finalists for the Outstanding Early-Career Investigator Award during the AHA-Basic Cardiovascular Sciences 2010 Scientific Sessions: Technological and Conceptual Advances in Cardiovascular Disease. His current research is supported by the National Scientist Development grant from the American Heart Association.

Education and Training

MSc: JIPMER, India, 1994.

PhD: Madurai Kamaraj University, India, 2002.

Postdoctoral Training: University of Cincinnati, Cincinnati, OH, 2002-2011.

Publications

Rajan S, Jagatheesan G, Karam CN, Alves ML, Bodi I, Schwartz A, Bulcao CF, D'Souza KM, Akhter SA, Boivin GP, Dube DK, Petrashevskaya N, Herr AB, Hullin R, Liggett SB, Wolska B, Solaro RJ, Wieczorek DF. Molecular and Functional Characterization of a Novel Cardiac Specific Human Tropomyosin Isoform. Circulation. 2010;121:410-18.

Jagatheesan G, Rajan S, Wieczorek DF. Investigations into tropomyosin function using mouse models. J Mol Cell Cardiol. 2010 May;48(5):893-8.

Wieczorek DF, Jagatheesan G, Rajan S. The role of tropomyosin in heart disease. In Tropomyosin (Ed.) Peter Gunning. Adv Exp Med Biol. 2008;644:132-42.

Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, and Wieczorek DF. Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res. 2007;101(2):205-14.

Rajan S, Williams SS, Jagatheesan G, Ahmed RP, Fuller-Bicer G, Schwartz A, Aronow BJ, Wieczorek DF. Microarray analysis of gene expression during early stages of mild and severe cardiac hypertrophy. Physiol Genomics. 2006;27;27(3):309-17.

Rajan S, Radhakrishnan J, Rajamanickam C. Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart. Basic Res Cardiol. 2003;98(1):39-49.

Grants

Translational and Post-translational Regulation of Tropomyosin in Normal and Cardiomyopathic Hearts. Principal Investigator. American Heart Association. Jan 2011 - Dec 2014.