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William Ridgway, MD

Professor, UC Department of Pediatrics

Phone: 513-558-4701

Email: william.ridgway@uc.edu

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Specialties

Autoimmunity; immunogenetics; T cells; T regulatory cells; type 1 diabetes; autoimmune biliary disease

Education and Training

MD: University of Rochester, NY.

Fellowship: Stanford University Medical Center.

Publications

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Yang GX, Wu Y, Tsukamoto H, Leung PS, Lian ZX, Rainbow DB, Hunter KM, Morris GA, Lyons PA, eterson LB, Wicker LS, Gershwin ME, Ridgway WM. CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease. J Immunol. 2011 Jan 15;186(2):1259-67.

Ridgway WM, Peterson LB, Todd JA, Rainbow DB, Healy B, Burren OS, Wicker LS. Gene-gene interactions in the NOD mouse model of type 1 diabetes. Adv Immunol. 2008;100:151-75.

Irie J, Reck B, Wu Y, Wicker LS, Howlett S, Rainbow D, Feingold E, Ridgway WM. Genome-wide microarray expression analysis of CD4+ T Cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes. J Immunol. 2008 Jan 15;180(2):1071-9.

Irie J, Wu Y, Sass DA, Ridgway WM. Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region. Immunogenetics. 2006 Feb;58(1):9-14.

Koarada S, Wu Y, Fertig N, Sass DA, Nalesnik M, Todd JA, Lyons PA, Fenyk-Melody J, Rainbow DB, Wicker LS, Peterson LB, Ridgway WM. Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain. J Immunol. 2004 Aug 15;173(4):2315-23.

Koarada S, Wu Y, Olshansky G, Ridgway WM. Increased nonobese diabetic Th1:Th2 (IFN-gamma:IL-4) ratio is CD4+ T cell intrinsic and independent of APC genetic background. J Immunol. 2002 Dec 1;169(11):6580-7.

Koarada S, Wu Y, Ridgway WM. Increased entry into the IFN-gamma effector pathway by CD4+ T cells selected by I-Ag7 on a nonobese diabetic versus C57BL/6 genetic background. J Immunol. 2001 Aug 1;167(3):1693-702.

Fassò M, Anandasabapathy N, Crawford F, Kappler J, Fathman CG, Ridgway WM. T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo. J Exp Med. 2000 Dec 18;192(12):1719-30.

Ridgway WM, Fassò M, Fathman CG. A new look at MHC and autoimmune disease. Science. 1999 Apr 30;284(5415):749, 751.

Ridgway WM, Ito H, Fassò M, Yu C, Fathman CG. Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response. J Exp Med. 1998 Dec 21;188(12):2267-75.

Grants

The Pathogenesis of Autoimmunity in a Murine Model of Primary Biliary Cirrhosis. Co-Principal Investigator. National Institutes of Health. 2006 - 2012.

dnTGF Beta RII Mice and PBC. Principal Investigator. National Institutes of Health. 2010 - 2014.

Soluble CD137 therapy for Type one diabetes. Principal Investigator. American Diabetes Association. 2011 - 2014.

Primary Biliary Cirrhosis: Molecular Genetics and Microbial Pathogenesis. Co-Principal Investigator. National Institutes of Health. 2010 - 2014.

Immunogenetic control of autoimmune biliary disease. Principal Investigator. Veterans Association. 2011 - 2015.