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High Res

Joseph D. Sherrill, PhD

Instructor, UC Department of Pediatrics

Phone: 513-803-0975

Email: joseph.sherrill@cchmc.org

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Biography

Dr. Sherrill first joined the Division of Allergy and Immunology as a research fellow in Dr. Marc Rothenberg’s lab where he began dissecting the genetic contribution of epithelial-derived genes to the pathogenesis of eosinophilic esophagitis (EoE). The central hypothesis of his studies is that single-nucleotide polymorphisms (SNP)s in epithelial-derived genes are contributory factors in the genetic and mechanistic development of EoE. His studies culminated in two first author publications in Nature Genetics and the Journal of Allergy and Clinical Immunology that identified EoE risk variants in the TSLP gene and its receptor. Dr. Sherrill is continuing to utilize his experience gained in modern genetic techniques (genome-wide association studies, exome sequencing, and RNA sequencing) and bioinformatics to investigate eosinophilic disease risk variants as the focus of his lab.

Recognized as a promising junior faculty member, Dr. Sherrill has received a T32 training grant, the Thrasher Research Fund Early Career Award and is a recipient of the NIH Loan Repayment Program as well as numerous travel awards from the American Academy of Allergy, Asthma, and Immunology and the American Partnership for Eosinophilic Disorders. Dr. Sherrill also received the top place award at the 2011 Digestive Health Center poster symposium for his work on desmoglein-1 in eosinophilic esophagitis.

Education and Training

PhD: University of Cincinnati, Cincinnati, OH, 2008.

Research Fellowship: Division of Allergy and Immunology, Cincinnati Children’s, Cincinnati, OH, 2008-2012.

Publications

View PubMed Publications

Sherrill JD, Rothenberg ME. Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. Journal of Allergy and Clinical Immunology. 2011;128(1):23-32.

Sherrill JD, Gao P, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa’ad AH, Butsch Kovacic M, Biagini Meyers JM, Bochner BS, He H, Khurana Hershey G, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2010;126(1):160-5.

Rothenberg ME*, Spergel JM*, Sherrill JD*, Annaiah K*, Martin LJ*, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nature Genetics. 2010;42(4):289-91.
*co-first author

Sherrill JD, Stropes MP, Schneider OD, Koch DE, Bittencourt FM, Miller JLC, Miller WE. Activation of intracellular signaling pathways by the murine cytomegalovirus G protein-coupled receptor M33 occurs via PLC-beta/PKC-dependent and -independent mechanisms. Journal of Virology. 2009;83(16):8141-52.

Sherrill JD, Miller, WE. Desensitization of Herpes-virus-encoded G protein-coupled receptors. Life Sciences. 2007;82(3-4):125-34.

Sherrill JD, Miller WE. G protein-coupled receptor (GPCR) kinase 2 regulates agonist-independent Gq/11 signaling from the mouse cytomegalovirus GPCR M33. Journal of Biological Chemistry. 2006;281(52):39796-805.

Grants

Genetic dysregulation of desmoglein-1 enhances allergic sensitization in eosinophilic esophagitis. Principal Investigator. Thrasher Research Fund Early Career Award. 2012.