Nathan Salomonis, PhD

I am a trained computational and experimental biologist who develops approaches to examine the interplay between diverse modes of gene regulation, including transcription, alternative splicing, genetics and epigenetics that underlie disease interaction networks.

I have co-authored more than 80 publications related to computational genomics and have more than 20 years’ experience directing the development of highly-used software applications for computational experts and biologists alike. My research group actively applies these and many other computational genomics techniques to diverse biological problems, including understanding the role of alternative splicing and neoantigen creation in cancer while defining lineage fate choices in differentiation and defining novel molecular mechanisms in human cardiovascular diseases.

We continue to develop new approaches for the integrative analysis of diverse molecular omics technologies including those for single-cell transcriptomics/epigenomics/ proteomics. We hope to ultimately apply insights from these computational approaches to develop new therapeutic strategies for difficult to treat pediatric cancers.

I have been fortunate to receive support from various internal awards, including:

• Cincinnati Children’s Hospital Medical Center Endowed Scholar recognition (2019)
• Academic and Research Committee (ARC) Award (2018)
• Trustee Award and Procter Scholar (TAPS) Program Award (2017)

Our work has been published in numerous high impact journals, including Nature, Nature Genetics, Cancer Discovery, Nature Methods, Cell Stem Cell and Nucleic Acids Research.