Clinical Interests

Connective tissue disorders; interventional genetics; molecular genetics

Research Interests

Management of connective tissue disorders; natural history of Ehlers-Danlos syndrome; clinical trials; discovery of new causative genes in connective tissue disorders 

PhD: George Washington University, Washington, DC, 1995.

MD: Indiana University, Indianapolis, IN, 1999.

Residency: Pediatrics / Human Genetics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 2004.

Fellowship: Clinical Molecular Genetics, Cincinnati Children's Hospital Medical Center, 2006.

Certification: Pediatrics, 2003; Clinical Genetics, 2005; Clinical Molecular Genetics, 2007.

Bendik EM, Tinkle BT, Al-Shuik E, Levin L, Martin A, Thaler R, Atzinger CL, Rueger J, Martin VT. Joint hypermobility syndrome: A common clinical disorder associated with migraine in women. Cephalalgia. 2011 Feb 2.

Sun GH, Samy RN, Tinkle BT, Cornelius RS, Brown DK. Craniometaphyseal dysplasia-induced hearing loss. Otol Neurotol. 2011 Feb;32(2):e9-10. 

Atzinger CL, Meyer RA, Khoury PR, Gao Z, Tinkle BT. Cross-Sectional and Longitudinal Assessment of Aortic Root Dilation and Valvular Anomalies in Hypermobile and Classic Ehlers-Danlos Syndrome. J Pediatr. 2010 Dec 28. 

Z Yazici, B Kline-Fath, T Laor,BT Tinkle.  Fetal MR imaging of Kniest dysplasia.  Pediatr Radiol. 2010 Mar;40(3):348-52.

Tinkle BT,Bird HA, Grahame R, Lavallee M, Levy HP, Sillence D. The lack of clinical distinction between the hypermobility type of Ehlers-Danlos syndrome and the joint hypermobility syndrome (a.k.a. hypermobility syndrome). Am J Med Genet. 2009 Nov;149A(11):2368-70.  

 Zarate YA, Mena R, Martin LJ, Steele P, Tinkle BT, Hopkin RJ. Experience with hemihyperplasia and Beckwith-Wiedemann syndrome surveillance protocol. Am J Med Genet A. 2009 Aug;149A(8):1691-7.

M Ednick, BT Tinkle, J Phromchairak, J Egelhoff, R Amin, N Simakajornboon. Sleep-related respiratory abnormalities and arousal pattern in achondroplasia during early infancy period. J Pediatr. 2009;155(4):510-5.

Mattheis PJ, Hickey F, Tinkle BT, Hopkin R:  Prenatal diagnosis: beyond decisions about termination. J Pediatr. 2008 Nov;153(5):728.

Burrow TA, Hopkin RJ, Leslie ND, Tinkle BT, Grabowski GA. Enzyme reconstitution/replacement therapy for lysosomal storage diseases. Curr Opin Pediatr. 2007 Dec;19(6):628-35.

Sutherell J, Zarate Y, Tinkle BT, Markham LW, Cripe LH, Hyland JC, Witte D, Hopkin RJ, Hinton RB. Novel fibrillin 1 mutation in a case of neonatal Marfan syndrome: the increasing importance of early recognition. Congenit Heart Dis. 2007 Sep;2(5):342-6.