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Biographies

Find another Doctor or Researcher

A photo of Gregory Tiao.

High Res

Greg M. Tiao, MD

Surgical Director, Liver Transplantation

Director, Small Bowel Program

Associate Director, Pediatric Surgery Training Program

Pediatric Surgeon

Associate Professor, Division of Pediatric Surgery

Phone: 513-636-4371

Fax: 513-636-7657

Email: greg.tiao@cchmc.org

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Specialties

Liver, kidney and small bowel transplantation; hepatobiliary disease; Neonatal surgery; biliary atresia; minimally invasive surgery

Biography

As a pediatric surgeon and a transplant surgeon, I am involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant when necessary. I see the many challenges a child and their family experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is my career goal. Our short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver.

Our overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction.Our focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, how infected cholangiocytes modify the microenvironment activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, I have defined an area of independence from Dr Jorge Bezerra, my primary research mentor.

Education and Training

BS: Northwestern University, Evanston, IL, 1986.

MD: University of Illinois, Chicago, IL, 1990.

Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997;Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.

Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002;Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.

Publications

Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G Ross ME. Chemoresistant hepatoblastoma in a patient with mosaic trisomy 18 treated with orthotopic liver transplantation. Peditr Blood Cancer 2011;56(3):498-500.

Bondoc A, Jafri M, Donnelly B, Mohanty S, McNeal M, Ward R, Tiao G. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J of Pediatric Surgery. 2009;44(8):1479-90. PMCID: PMC2748872

Jafri M, Donnelly B, Bondoc A, Allen S, Tiao G. Cholangiocyte secretion of chemokines in experimental biliary atresia. J of Pediatric Surgery. 2009;44(3):500-507. PMCID: PMC2730110

Jafri M, Donnelly B, Allen S, Bondoc A, McNeal M, Rennert PD, Weinreb PH, Ward R, Tiao G. Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia. Am J Physiol Gastrointest Liver Physiol. 2008;295(1):G16-G26. PMCID: PMC2494723

Allen SR, Jafri M, Donnelly B, McNeal M, Witte D, Bezerra J, Ward R, Tiao GM. Effect of rotavirus strain on the murine model of biliary atresia. J Virol. 2007;81(4):1671-9.

Jafri M, Donnelly B, McNeal M, Ward R, Tiao G. MAPK signaling contributes to rotaviral-induced cholangiocyte injury and viral replication. Surgery. 2007;142(2):192-201.

Tiao GM, Alonso MH, Ryckman FC. Pediatric liver transplantation. Semin Pediatr Surg. 2006;15(3):218-227.

Tiao G, Alonso M, Bezerra J, Yazigi N, Heubi J, Balistreri W, Bucuvalas J, Ryckman F. Liver transplantation in children under one year of age-the cincinnati experience. J Pediatr Surg. 2005;40(1):268-273.

Zhang DY, Sabla G, Shivakumar P, Tiao G, Sokol RJ, Mack C, Schneider GL, Aronow B, Bezerra JA. Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia. Hepatology. 2004;39(4):954-962.

Shivakumar P, Cambell KM, Sabla GE, Mietke A, Tiao G, McNeal NM, Ward RL, Bezerra JA. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest. 2004;114(3):322-329.

Grants

The Molecular Determinants of Virus Induced Biliary Induced Biliary Asteria. Principal Investigator. Apr 2011-Marh 2016.

Intracellular Signaling Pathways and Virus Induced Biliary Asteria. Principal Investigator. May 2010-Apr 2012.

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