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High Res

Charles V. Vorhees, PhD

Professor, UC Department of Pediatrics

Phone: 513-636-8622

Fax: 513-636-3912

Email: charles.vorhees@cchmc.org

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Specialties

Effects of amphetamines on brain development, behavior, and neurotoxicity; neurobiological substrates of learning and memory; proteins for neurotransmitter receptors, second messenger transduction, and regulators of signaling pathways.

Visit the Vorhees-Williams-Skelton Lab.

Biography

Charles Vorhees, PhD, has served on numerous National Institutes of Health site visit committees, special emphasis panels, and ad hoc review committees since 1984. He was a member of a study section from 1994-1998, and served as interim chair in 1997. Dr. Vorheeshas also reviewed grant applications for the National Science Foundation, Veterans Administration, Wellcome Trust, March of Dimes, and other agencies. He has served on advisory committees to the US Food and Drug Administration, US Environmental Protection agency, National Research Council, several private foundations, and a number of pharmaceutical companies.

Dr. Vorhees was Director of the Graduate Program in Molecular and Developmental Biology at the University of Cincinnati College of Medicine from 1998-2004.

Visit the Vorhees Lab Site

Visit the Animal Behavioral Core Site

Education and Training

MA: Neurobiology Program, Vanderbilt University, Nashville, TN, 1973.

PhD: Neurobiology Program, Vanderbilt University, Nashville, TN, 1976.

Publications

View PubMed Publications

Graham DL, Grace CE, Braun AA, Schaefer TL, Skelton MR, Tang PH, Vorhees CV, Williams MT. Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels in rats. Int J Dev Neurosci. 2011 Feb;29(1):45-55.

Skelton MR, Schaefer TL, Graham DL, Degrauw TJ, Clark JF, Williams MT, Vorhees CV. Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency. PLoS One. 2011 Jan 13;6(1):e16187.

Curran CP, Vorhees CV, Williams MT, Genter MB, Miller ML, Nebert DW. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicol Sci. 2011 Jan;119(1):189-208.

Braun AA, Skelton MR, Vorhees CV, Williams MT. Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents. Pharmacol Biochem Behav. 2011 Jan;97(3):406-15.

Schaefer TL, Grace CE, Gudelsky GA, Vorhees CV, Williams MT. Effects on plasma corticosterone levels and brain serotonin from interference with methamphetamine-induced corticosterone release in neonatal rats. Stress. 2010 Nov;13(6):469-80.

Schaefer TL, Lingrel JB, Moseley AE, Vorhees CV, Williams MT. Targeted mutations in the Na,K-ATPase alpha 2 isoform confer ouabain resistance and result in abnormal behavior in mice. Synapse. 2010 Oct 8.

Herring NR, Gudelsky GA, Vorhees CV, Williams MT. (+)-Methamphetamine-induced monoamine reductions and impaired egocentric learning in adrenalectomized rats is independent of hyperthermia. Synapse. 2010 Oct;64(10):773-85.

Zhu H, Mingler MK, McBride ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Williams MT, Vorhees CV, Rothenberg ME. Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1. Psychoneuroendocrinology. 2010 Sep;35(8):1119-32.

Vorhees CV, He E, Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Amos-Kroohs R, Williams MT. Comparison of (+)-methamphetamine, ±-Methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze. Synapse. 2010 Aug 20.

Grace CE, Schaefer TL, Graham DL, Skelton MR, Williams MT, Vorhees CV. Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels. Int J Dev Neurosci. 2010 Jun;28(4):331-42.