Charles V. Vorhees, PhD

Professor, UC Department of Pediatrics

Phone 513-636-8622

Fax 513-636-3912

Email charles.vorhees@cchmc.org

Principal areas of investigation are how drugs, genetic mutations, environmental agents, and stressors affect prenatal and neonatal brain development and behavior.  The lab is particularly interested in the long-term effects of such perturbations on cognitive development.

Visit the Vorhees-Williams-Skelton Lab.

Dr. Vorhees came to Cincinnati Children’s in 1976 as a postdoctoral research scholar and was recruited to the faculty in 1978 as assistant professor. He was promoted to associate professor in 1982, tenured in 1984, and promoted to professor in 1988 with primary appointment in pediatrics and joint appointment in environmental health. He is co-director of the Animal Behavior Core and program director of the Teratology Training Program.  He is on the graduate faculty of the Graduate Programs in Neuroscience (NS) and Molecular and Developmental Biology (MDB). He is section editor of the journal Neurotoxicology and Teratology and served as editor-in-chief for nine years. He was director of the MDB Graduate Program for six years and served in other leadership positions for 15 years. Dr. Vorhees has also served in leadership positions in the NS Program and is currently a member of the Admissions Committee. Dr. Vorhees has been extramurally funded for 35 years, receiving grants from NIH, NSF, FDA and other agencies. He holds an NIH T32 training grant funded for years 36-40 through 2017.  He is a founding member of the Neurobehavioral Teratology Society in 1977 and was elected president in 1984-85 and 2012-13.  He is an elected member of Sigma Xi, an Eli Lilly Distinguished Lecturer in 1990, and a Society for Neuroscience Grass Foundation Lecturer in 2002.  Dr. Vorhees has served on multiple FDA, NRC, and EPA advisory panels.  He has been an NIH grant reviewer on varies committees for more than 26 years.  He has also reviewed grants for NSF, VA, EPA; March of Dimes, and other agencies and foundations in the U.S.; and for funding agencies in Israel, Ireland, Great Britain, and New Zealand.  His research focuses on brain development and behavior.  As of 2013 he has published than more 276 journal articles and book chapters.

Visit the Vorhees Lab Site

Visit the Animal Behavioral Core Site

MA: Neurobiology Program, Vanderbilt University, Nashville, TN, 1973.

PhD: Neurobiology Program, Vanderbilt University, Nashville, TN, 1976.

Hautman ER, Williams MT, Vorhees CV, Skelton MR. Female mice heterozygous for creatine transporter deficiency have reduced brain creatine, are hypoactive, but show no cognitive deficits. J Inherited Metab Dis. 2013. (In press).

Sun Y, Zamzow M, Ran H, Zhang W, Quinn B, Barnes S, Witte DP, Setchell KDR, Williams MT, Vorhees CV, Grabowski GA. Tissue-specific effects of saposin A and saposin B on glycosphingolipids degradation in mutant mice. Hum Mol Genet. 2013. (In press).

Amos-Kroohs RM, Williams MT, Braun AA, Graham DL, Webb CL, Birtles TS, Greene RM, Vorhees CV, Pisano MM. Neurobehavioral phenotype of C57BL/6J mice prenatally and neonatally exposed to cigarette smoke. Neurotoxicol Teratol. 2013;35, 34-45.

Schaefer TL, Grace CE, Braun AA, Amos-Kroohs RM, Graham DL, Skelton MR, Williams MT, Vorhees CV. Cognitive impairments from developmental exposure to serotonergic drugs: citalopram or MDMA. Int J Neuropsychopharmacol. 2013;16, 1383-94.

Graham DL, Amos-Kroohs RM, Braun AA, Grace CE, Schaefer TL, Skelton MR, Vorhees CV, Williams MT. Neonatal (+)-methamphetamine exposure in rats alters adult locomotor responses to dopamine D1 and D2 agonists and to a glutamate NMDA receptor antagonist, but not to serotonin agonists. Int J Neuropsychopharmacol. 2012;16, 377-391.

Vorhees CV, Graham DL, Braun AA, Schaefer TL, Skelton MR, Richtand NM, Williams MT. Prenatal immune challenge in rats: Altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to Poly IC. Synapse. 2012;66(8), 725-737.

Schaefer TL, Braun AA, Amos-Kroohs RM, Williams MT, Ostertag E, Vorhees CV. A new model of Pde4d deficiency: Genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects. Genes Brain Behav. 2012;11(5), 614-622.

Chen Y, Curran CP, Nebert DW, Patel KV, Williams MT, Vorhees CV. Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm(-/-) knockout miceNeurotoxicol Teratol. 2012;34, 450-457.

Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Burns LA, Amos-Kroohs RM, Williams MT, Vorhees CV. Distinct periods of developmental sensitive to the effects 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats. Int J Neuropsychopharmacol. 2012;15, 811-824.

Braun AA, Graham DL, Schaefer TL, Vorhees CV, Williams MT. Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats. Neurobiol Learn Mem. 2012;97(4), 402-408.

Prenatal SSRI Exposure and ASD. Principal Investigator. Congressionally Directed Medical Research Program, Department of Defense. 2013-2015.

Latrophilin-3 and ADHD: A new potential mechanism. Principal Investigator. National Institutes of Health.  2013-2015.

Training Grant in Teratology. Principal Investigator. National Institutes of Health. 2012-2017.