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High Res

Christopher Wylie, PhD

Director, Division of Developmental Biology

Professor, UC Department of Pediatrics

Phone: 513-636-2090

Fax: 513-636-4317

Email: christopher.wylie@cchmc.org

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Specialties

Visit the Wylie-Heasman Lab.

Biography

After spending his early years in Kenya, Dr. Wylie moved to England. He attended University College Hospital Medical School, where he gained a BSc in Anatomy, and a PhD in Developmental Biology. He held faculty positions at University College London, and St. George's Hospital Medical School before taking the Frederick James Quick Chair of Biology at Cambridge University in 1989. In 1994, he accepted the Martin Lenz Harrison Chair of Development and Genetics at the University of Minnesota School of Medicine in 1994, where he led the University of Minnesota Developmental Biology Center. In 2000, he moved to the Cincinnati Children's Hospital to become the Director of the Developmental Biology Division, and the first William K. Schubert Professor in the Department of Pediatrics. He was the founding Editor of the International journal Development, and has served as President of the Society for Developmental Biology.

Education and Training

PhD: University of London, UK.

Publications

View PubMed Publications

Dahia CL, Mahoney EJ, Durrani AA, Wylie C. Intercellular Signaling Pathways Active During and After Growth and Differentiation of Lumbar Vertebral Growth Plate. Spine (Phila Pa 1976). 2011 Jun 15;36(14):1071-80.

Cha SW, Tadjuidje E, White J, Wells J, Mayhew C, Wylie C, Heasman J. Wnt11/5a complex formation caused by tyrosine sulfation increases canonical signaling activity. Curr Biol. 2009 Sep 29;19(18):1573-80.

Gu Y, Runyan C, Shoemaker A, Surani A, Wylie C. Steel factor controls primordial germ cell survival and motility from the time of their specification in the allantois and provides a continuous niche throughout their migration. Development. 2009;136:1296-303.

Nandadasa S, Tao Q, Menon N, Heasman J, Wylie C. N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements. Development. 2009;136:1327-38.

Dahia C, Mahoney E, Durrani A, Wylie C. Postnatal growth, differentiation, and ageing of the mouse intervertebral disc. Spine. 2009;34:447-55.

Dahia C, Mahoney E, Durrani A, Wylie C. Intercellular pathways active during intervertebral disc growth, differentiation and ageing. Spine. 2009;34:456-62.

Deng J, Lang S, Wylie C, Hammes S. The Xenopus laevis isoform of G protein-coupled receptor 3 (GPR3) is a constitutively active cell surface receptor that participates in maintaining meiotic arrest in X. laevis oocytes. Mol Endocrinol. 2008;22:1853-65.

Cha SW, Tadjuidje E, Tao Q, Wylie C, Heasman J. Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation. Development. 2008;135: 3719-29.

Runyan C, Gu Y, Shoemaker A, Looijenga L, Wylie C. The distribution and behavior of extragonadal primordial germ cells in Bax mutant mice suggest a novel origin for sacrococcygeal germ cell tumors. Int J Dev Biol. 2008;52:333-44.

Mir A, Kofron M, Heasman J, Mogle M, Lang S, Birsoy B, Wylie C. Long- and short-range signals control the dynamic expression of an animal hemisphere-specific gene in Xenopus. Dev Biol. 2008;315(1):161-72.