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Janet Wylie, PhD

Professor, UC Department of Pediatrics

Phone: 513-636-8564

Email: janet.wylie@cchmc.org

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Specialties

Clinical Interests

Signaling pathways and transcription factors regulating germ layer formation

Research Interests

Wnt pathways and signaling inputs; embryo formation

Visit the Wylie-Heasman Lab.

Biography

Janet Heasman has always been interested in the question of how the single cell, the fertilized egg, develops into a complex embryo, that is intricately patterned both in terms of its tissue types and axes. Dr Heasman studies this in the frog Xenopus laevis. To read more of her background see the interview in J Cell Sci. 2004 117:1617-8 by Fiona Watt.

Education and Training

BSc: University College, London, UK, 1974.

PhD: University Of London, 1979.

Publications

View PubMed Publications

Blythe SA, Cha SW, Tadjuidje E, Heasman J, Klein PS. beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Dev Cell. 2010 Aug 17;19(2):220-31.

Cha SW, Heasman J. Using oocytes for Wnt signaling assays: paracrine assays and Wnt-conditioned medium. Methods. 2010 May;51(1):52-5.

Cha SW, Tadjuidje E, White J, Wells J, Mayhew C, Wylie C, Heasman J. Wnt11/5a complex formation caused by tyrosine sulfation increases canonical signaling activity. Curr Biol. 2009 Sep 29;19(18):1573-80.

Nandadasa S, Tao Q, Menon NR, Heasman J, Wylie C. N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements. Development. 2009 Apr;136(8):1327-38.

Mir A, Heasman J. How the mother can help: studying maternal Wnt signaling by anti-sense-mediated depletion of maternal mRNAs and the host transfer technique. Methods Mol Biol. 2008;469:417-29.

Cha SW, Tadjuidje E, Tao Q, Wylie C, Heasman J. How the mother can help: studying maternal Wnt signaling by anti-sense-mediated depletion of maternal mRNAs and the host transfer technique. Development. 2008 Nov;135(22):3719-29.

Mir A, Kofron M, Heasman J, Mogle M, Lang S, Birsoy B, Wylie C. Long- and short-range signals control the dynamic expression of an animal hemisphere-specific gene in Xenopus. Dev Biol. 2008 Mar 1;315(1):161-72.

Cha JY, Birsoy B, Kofron M, Mahoney E, Lang S, Wylie C, Heasman J. The role of FoxC1 in early Xenopus development. Dev Dyn. 2007 Oct;236(10):2731-41.

Tao Q, Nandadasa S, McCrea PD, Heasman J, Wylie C. The role of FoxC1 in early Xenopus development. Development. 2007 Jul;134(14):2651-61.

Mir A, Kofron M, Zorn AM, Bajzer M, Haque M, Heasman J, Wylie CC. FoxI1e activates ectoderm formation and controls cell position in the Xenopus blastula. Development. 2007 Feb;134(4):779-88.