Peter S. White, PhD

Director, Division of Biomedical Informatics

Professor, UC Department of Biomedical Informatics

Phone 513-803-4172

Email peter.white@cchmc.org

Clinical

Bioinformatics; biomedical informatics; genome informatics

Peter White, PhD, is the chair of the Division of Biomedical Informatics at the University of Cincinnati College of Medicine and Cincinnati Children's. In this role, he oversees informatics research and resources at both institutions, including academic, educational, data services, software development, and Research IT missions. Prior to 2014, Dr. White was research associate professor of pediatrics and section chief of Clinical Informatics at the University of Pennsylvania, and the recipient of the David Lawrence Altschuler Endowed Chair in Genomics and Computational Biology at The Children’s Hospital of Philadelphia (CHOP), where he served as director of the Center for Biomedical Informatics, faculty advisor of CHOP's Bioinformatics Core Facility, co-director of CHOP's Division of Genome Diagnostics, and co-director of the Bioinformatics in Translation section of the Penn/CHOP Clinical and Translational Science Award.

In his research career, Dr. White has explored the development and application of novel approaches for disease gene discovery, including identifying causative genes for neuroblastoma, ADHD, autism, and congenital heart defects. He has also developed innovative approaches for integrating and disseminating clinical, phenotypic, and molecular data to researchers for promoting discovery and hypothesis validation. Dr. White has recently played a lead informatics role on a number of national data projects, including the NICHD Newborn Screening Translational Research Network, the NHLBI Bench to Bassinet Program, the NHGRI Clinical Sequencing and Exploratory Research and IGNITE Consortia, and the NIDCD Audiology and Genetics Database.

PhD: Washington University, St. Louis, MO, 1993.

Masino AJ, Dechene ET, Dulik MC, Wilkens A, Spinner NB, Krantz ID, Pennington JW, Robinson PN, White PS. Clinical phenotype-based gene prioritization: An initial study using semantic similarity and the Human Phenotype Ontology. BMC Bioinformatics. In press.

D’Alessandro LCA, Werner P, Xie HM, Hakonarson H, White PS, Goldmuntz E. The prevalence of 16p12.1 microdeletion in patients with left-sided cardiac lesions. Congenit Heart Dis. 2014; 9:83-86.

Pennington JW, Ruth B, Italia MJ, Miller J, White PS. Harvest. A Web-based biomedical data discovery and reporting application development platform. J Am Med Inform Assoc. 2014; 21:379-383.

Tarczy-Hornoch P, Amendola L, Aronson SJ, Garraway L, Gray S, Grundmeier RW, Hindorff LA, Jarvik G, Karavite D, Lebo M, Plon SE, Van Allen E, Weck KE, White PS, Yang Y. A survey of informatics approaches to whole exome and whole genome clinical reporting in the electronic medical record. Genet Med. 2013; 15:824-834.

Zhang Z, Leipzig J, Sasson A, Perin JC, Xie M, Sarmady M, Warren P, White P. Efficient digest of high-throughput sequencing data in a reproducible report. BMC Bioinformatics. 2013; 14 (Suppl 11):S3.

Tropeano M, Ahn JW, Dobson RJ, Breen G, Rucker J, Dixit A, Pal DK, McGuffin P, Farmer A, White PS, Andrieux J, Vassos E, Ogilvie CM, Curran S, Collier DA. Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders. PLOS One. 2013; 8:e61365.

Zaidi S, Choi M, Wakimoto H, Ma L, Jianming J, Overton JD, Bjornson RD, Breitbart R, Carriero NJ, Cheung YH, Deanfield J, Glessner J, Hakonarson H, Italia M, Kaltman JR, Kaski J, Kim R, Kline JK, Lee T, Leipzig J, Alexander Lopez, Mane SM, Mitchell LE, Newburger J, Pe'er I, Porter G, Roberts A, Sachidanandam R, Sanders S, Seiden HS, State M, Subramanian S, Tikhonova IR, Warburton D, Wei Z, White PS, Williams IA, Zhao H, Seidman J, Brueckner M, Chung WK, Gelb BD, Goldmuntz E, Seidman CE, Lifton RP. Increased frequency of de novo mutations in histone modifying genes in congenital heart disease. Nature. 2013; 498:220–223.

Gai X, Xie HM, Perin JC, Takahashi N, Murphy K, Wenocur AS, D’arcy M, O’Hara RJ, Goldmuntz E, Grice DD, Shaikh TH, Hakonarson H, Buxbaum JD, Elia J, White PS. Rare structural variation of synapse and neurotransmission genes in autism. Molecular Psychiatry. 2012; 17:402-411.

Elia J, Joseph T. Glessner JT, Wang K, Takahashi N, Shtir CJ, Hadley D, Sleiman PMA, Haitao Zhang3, Kim CE, Robison R, Lyon GJ, Flory JH, Bradfield JP, Imielinski M, Hou C, Frackelton EC, Chiavacci RM, Sakurai T, Rabin C, Middleton FA, Thomas KA, Garris M, Mentch F, Freitag CM, Steinhausen H-C, Todorov AA, Reif A, Rothenberger A, Franke B, Mick EO, Roeyers H, Buitelaar J, Lesch K-P, Banaschewski T, Ebstein RP, Mulas F, Oades RD, Sergeant J, Sonuga-Barke E, Renner TJ, Marcel Romanos M, Romanos J, Warnke A, Walitza S, Meyer J, Pálmason H, Seitz C, Loo SK, Smalley SL, Joseph Biederman J, Kent L, Asherson P, Anney RJL, Gaynor JW, Shaw P, Devoto M, White PS, Grant SFA, Buxbaum JD, Rapoport JL, Williams NM, Nelson SF, Faraone SV, Hakonarson H. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nature Genetics. 2012; 44:78-84.

Elia J, Gai X, Hakonarson H, White PS. Structural variations in attention-deficit hyperactivity disorder. The Lancet. 2011; 377:377-378.

NHLBI Pediatric Translational Consortium Administrative Coordinating Center. Co-investigator. National Heart, Lung, and Blood Institute (NHLBI)/ National Institutes of Health (NIH). Mar 2011-Aug 2015.

Cincinnati Center for Clinical and Translational Sciences and Training. Co-investigator. National Center for Advancing Translational Sciences (NCATS) / National Institutes of Health (NIH). Apr 2009-Mar 2015.