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Susanne Wells, PhD

Director, Epithelial Carcinogenesis and Stem Cell Program

Director, Postdoctoral Office

Associate Professor, UC Department of Pediatrics

Phone: 513-636-5986

Email: susanne.wells@cchmc.org

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Specialties

Squamous cell carcinoma; mechanisms by which the HPV oncogenes subvert the host cell machinery to promote abnormal cell growth and cancer; role of specific cellular HPV targets in viral replication and cellular transformation

Visit the Wells Lab.

Biography

Susanne Wells graduated from the University of Konstanz, Germany, with a degree in Biology. She completed her PhD in Molecular Biology at the State University of Stony Brook, NY, and her Postdoctoral Fellowship at Harvard Medical School, MA. Dr. Wells moved to Cincinnati Children's Hospital Medical Center in 2002 to study human papillomavirus infection and associated carcinogenesis.

Education and Training

BS: Biology, University of Konstanz, Germany, 1992.

PhD: Molecular Genetics, State University of Stony Brook, NY, 1997.

Postdoctoral Fellowship: Molecular Virology, Harvard Medical School, Boston, MA.

Publications

View PubMed Publications

Privette Vinnedge, L. M., Kappes, F., Nassar, N. and Wells, S. I. 2012. Stacking the DEK: from chromatin topology to cancer stem cells. Cell Cycle. In process.

Romick-Rosendale, L. E., Lui, V. W., Grandis, J. R., and Wells, S. I. 2012. The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma. Mutation Research. In press.

Privette Vinnedge, L. M., Ho, S.-M., Wikenheiser-Brokamp, K. A., Wells, S. I. 2012. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLOS ONE, In process.

Yablonska, S., Hoskins, E. E., Wells, S. I., Khan, S. A. 2012. Identification of miRNAs dysregulated in human foreskin keratinocytes (HFKS) expressing the human papillomavirus (HPV) Type 16 E6 and E7 oncoproteins. Epub ahead of print.

Hoskins, E. E., Morreale, R. J., Werner, S. P., Higginbotham, J. M., Laimins, L. A., Lambert, P. F., Brown, D. R., Gillison, M. L., Nuovo, G. J., Witte, D. P., Kim, M.-O, Davies, S. M., Mehta, P. A., Butsch Kovacic, M., Wikenheiser-Brokamp, K. A., Wells, S. I. 2012. The Fanconi anemia pathway limits human papillomavirus replication. Journal of Virology. 86; 8131-8138

Wise-Draper, T. M., Draper, D. J., Gutkind, J. S., Molinolo, A. A., Wikenheiser-Brokamp, K. A., and Wells, S. I., 2012. Future directions and treatment strategies for head and neck squamous cell carcinomas. Transl. Res. 160; 167-177.

Morrison, M. A., Morreale, R. J., Akunuru, S., Kofron, M., Zheng, Y., Wells, S. I. 2011. Targeting the human papillomavirus E6 and E7 oncogenes through expression of the BPV1 E2 protein stimulates cellular motility. Journal of Virology. 85: 10487-10498.

Kavanaugh, G. M., Wise-Draper, T. M., Morreale, R. J., Morrison, M. A., Gole, B., Schwemberger, S., Tichy, E. D., Lu, L., Babcock, G. F., Wells, J. M., Drissi, R., Bissler, J. J., Stambrook, P. J., Andreassen, P. R., Wiesmüller, L., Wells, S. I. 2011. The human DEK oncogene regulates DNA damage response signaling and repair. Nucl. Acids Res. 39: 7465-7476.

Privette Vinnedge, L. M., McClaine, R., Wagh, P. K., Wikenheiser-Brokamp, K. A., Waltz, S. E., Wells, S. I. 2011. The human DEK oncogene stimulates b-catenin signaling, invasion and mammosphere formation in breast cancer. Oncogene. 30: 2741-2752.

Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Tolle, K., Hoskins, E. E., Kalinichenko, V. V., Wells, S. I., Zorn, A. M., Shroyer, N. F., and Wells, J. M. 2011. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 470: 105-109.

Grants

Role and regulation of the human DEK proto-oncogene. Principle Investigator. National Institutes of Health. 2006 - 2011.

Fanconi Anemia and HPV transformation. Principle Investigator. National Institutes of Health. 2010 - 2015. #2RO1 CA102357.

Fanconi Anemia as a Model for Susceptibility to Human Papillomavirus Infection. Principle Investigator. National Institutes of Health. 2011 - 2016. #1RO1 HL108102-01.