A photo of Susanne Wells.

Susanne Wells, PhD

Director, Epithelial Carcinogenesis and Stem Cell Program

Director, Postdoctoral Office

Professor, UC Department of Pediatrics

Phone 513-636-5986

Fax 513-636-3549

Email susanne.wells@cchmc.org

Squamous cell carcinoma; mechanisms by which the HPV oncogenes subvert the host cell machinery to promote abnormal cell growth and cancer; role of specific cellular HPV targets in viral replication and cellular transformation

Visit the Wells Lab.

Susanne Wells graduated from the University of Konstanz, Germany, with a degree in Biology. She completed her PhD in Molecular Biology at the State University of Stony Brook, NY, and her Postdoctoral Fellowship at Harvard Medical School, MA. Dr. Wells moved to Cincinnati Children's Hospital Medical Center in 2002 to study human papillomavirus infection and associated carcinogenesis.

BS: Biology, University of Konstanz, Germany, 1992.

PhD: Molecular Genetics, State University of Stony Brook, NY, 1997.

Postdoctoral Fellowship: Molecular Virology, Harvard Medical School, Boston, MA.

Bahassi, M., Li, Y-Q, Wise-Draper, T. M., Deng, L., Wang, J., Colleen, D., Wilson, K. M., Wells, S. I., Stambrook, P. J. Rixe,0. 2013. A somatic mutation in the EGFR ligand-binding domain is associated with increased sensitivity to cetuximab. European J. Cancer, in press

Privette Vinnedge, L. M., Ho,S.-M., Wikenheiser-Brokamp, K. A., Wells, S. I. 2012. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLOS One. 7(10):e46985. doi: 10.1371.

Hoskins, E. E., Morreale, R. J., Werner, S. P., Higginbotham, J. M., Laimins, L.A., Lambert, P. F., Brown, D. R., Gillison, M. L., Nuovo, G. J., Witte, D.P., Kim, M-O, Davies, S.M., Mehta, P. A., Butsch Kovacic, M., Wikenheiser-Brokamp, K. A., Wells, S. I. 2012. The Fanconi anemia pathway limits human papillomavirus replication. Journal of Virology. 86; 8131- 8138.

Wise-Draper, T. M., Draper, D. J., Gutkind, J. S., Molinolo, A. A., Wikenheiser-Brokamp, K. A., and Wells, S. I., 2012. Future directions  and treatment strategies for head and neck squamous cell carcinomas. Transl. Res. 160; 167-177.

Morrison, M.A., Morreale, R. J., Akunuru, S., Kofron, M., Zheng, Y., Wells, S. I. 2011. Targeting the human papillomavirus E6 and E7 oncogenes through  expression of the BPV1 E2 protein stimulates cellular motility. Journal of Virology. 85: 10487-10498.

Myers, K. C., Bleesing, J. J., Davies, S.M., Zhang, X., Martin, L. J., Mueller, R., Harris, R. E., Filipovich, A. H., Kovacic, M. B., Wells, S. I., Mehta, P. A. 2011. Impaired immune function in children with Fanconi anaemia. Br. J. Haematol. 154: 234-240.

Kavanaugh, G. M., Wise-Draper, T. M., Morreale, R. J., Morrison, M.A., Gole, B., Schwemberger, S., Tichy, E. D., Lu, L., Babcock, G. F., Wells, J. M., Drissi, R., Bissler, J. J.,Stambrook, P. J., Andreassen, P. R.,Wiesmuller, L., Wells, S. I. 2011. The human DEK oncogene regulates DNA damage response signaling and repair. Nucl. Acids Res. 39:7465-7476.

Privette Vinnedge, L. M., McClaine, R., Wagh, P. K., Wikenheiser-Brokamp, K. A., Waltz, S. E., Wells, S. I. 2011. The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer. Oncogene. 30: 2741-2752.

Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Toile, K.,Hoskins, E. E., Kalinichenko, V. V., Wells, S. I., Zorn, A. M.,Shroyer, N. F., and Wells, J. M. 2011. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 470: 105-109.

Meyer, S. E., Peace B. E., Bahassi el M., Kavanaugh G. M., Wagh, P. K., Robbins S. B., Yin M.,Wells S. I., Zinser G. M., Stambrook P. J., and Waltz S. E. 2010. Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice. Cancer Letters, 296: 186-193.

Research Innovation Fund Award
Title:
Identification of FA disease biomarkers using NMR-based metabonomics
PI: Susanne Wells
Project Period: 2013-2014
Funding by: Cincinnati Children's Hospital Medical Center


2R01 CA116316
Title:
Role and regulation of the human DEK proto-oncogene
PI: Susanne Wells
Project Period: 2012 – 2017
Funding by: National Institutes of Health

DOD Idea Award
Title:
Targeting the Ron-DEK signaling axis in breast cancer
PI: Susanne Wells and Susan Waltz
Project Period: 2012 – 2014
Funding by: Department of Defense

2R01 CA102357
Title:
Fanconi Anemia and HPV transformation
PI: Susanne Wells
Project Period: 2009 – 2014
Funding by: National Institutes of Health