Chronic lung disease; air-blood barrier; identification of cytoprotective pathways

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BS: Biology, Bob Jones University, Greenville, South Carolina, 1975.

MS: Embryology, Hahnemann Medical College, Philadelphia, Pennsylvania, 1979.

PhD: Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 1983.

Postdoc: Molecular Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 1986.

Besnard V, Matsuzaki Y, Clark JC, Xu Y, Wert SE, Ikegami M, Stahlman MT, Weaver TE, Hunt AN, Postle AD, Whitsett JA. Conditional Deletion of Abca3 in Alveolar Type II Cells Alters Surfactant Homeostasis in Newborn and Adult Mice. Am J Physiol Lung Cell Mol Physiol. 2010 Feb 26.

Yang L, Johansson J, Ridsdale R, Willander H, Fitzen M, Akinbi HT, Weaver TE. Surfactant protein B propeptide contains a saposin-like protein domain with antimicrobial activity at low pH. J Immunol. 2010 Jan 15;184(2):975-83.

Whitsett JA, Wert SE, Weaver TE. Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease. Annu Rev Med. 2010;61:105-19. Review.

Wang M, Bridges JP, Na CL, Xu Y, Weaver TE. Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C. J Biol Chem. 2009 Nov 27;284(48):33377-83.

Conkright JJ, Apsley KS, Martin EP, Ridsdale R, Rice WR, Na CL, Yang B, Weaver TE. Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol. 2010 Feb;42(2):181-9.

Ikegami M, Weaver TE, Grant SN, Whitsett JA. Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation. Am J Respir Cell Mol Biol. 2009 Oct;41(4):433-9. 

Dong M, Bridges JP, Apsley K, Xu Y, Weaver TE. ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Mol Biol Cell. 2008 Jun;19(6):2620-30.

Stahlman MT, Besnard V, Wert SE, Weaver TE, Dingle S, Xu Y, von Zychlin K, Olson SJ, Whitsett JA. Expression of ABCA3 in developing lung and other tissues. J Histochem Cytochem. 2007 Jan;55(1):71-83.

Nash JA, Ballard TN, Weaver TE, Akinbi HT. The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivo. J Immunol. 2006 Jul 1;177(1):519-26. 

Akei H, Whitsett JA, Buroker M, Ninomiya T, Tatsumi H, Weaver TE, Ikegami M. Surface tension influences cell shape and phagocytosis in alveolar macrophages. Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L572-9.