Mei Xin, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-3464

Email mei.xin@cchmc.org

Cardiovascular development; heart growth and regeneration; cardiomyocyte proliferation.

Mei Xin received her PhD from the University of Texas Southwestern Medical Center at Dallas. She completed her postdoctoral training in Eric Olson’s laboratory where she investigated microRNAs and signaling molecules regulating smooth muscle and cardiac muscle growth. In August 2013, Dr. Xin moved to Cincinnati Children’s Hospital Medical Center to study cardiovascular development and diseases.

MS: Robert Wood Johnson Medical School, Piscataway, NJ.

PhD: The University of Texas Southwestern Medical Center, Dallas, TX.

Postdoctoral Fellowship: The University of Texas Southwestern Medical Center, Dallas, TX.

Das M, Tanigawa S, Karner CM, Xin M, McNeil H, Lum L, Chen C, Olson EN, Alan O. Perantoni AO, Carroll TJ. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nature Cell Biology. 2013 Oct 1;15(10):1260.

Xin M, Sutherland LB, Qi X, McAnally J, Richardson JA, Sadek H., Bassel-Duby R, Olson EN.       Yap Controls heart regeneration and repair. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44.

Xin M, Bassel-Duby R and Olson EN. Cardiac Development as a Foundation for Adult Heart Regeneration and Repair. (Invited review) Nature Reviews Molecular Cell Biology. 2013 Aug;14(8):529-41.

Cruso P, Dempsie1 Y, Stevens H, McDonald RA, Long L, Lu R, White K, Mair K, Southwood M, Upton P, Xin M, van Rooij E, Olson E, Morrell NW, MacLean MR, Baker AH. A role for miR-145 in pulmonary arterial hypertension: Evidences from mouse models and patient samples. Circ Res. 2012 Jul 20;111(3):290-300.

Xin M, Kim Y, Sutherland LB, Qi X, McAnally J, Schwartz RJ, Richardson JA, Bassel-Duby R, Olson EN. Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Science Signal. 2011 Oct 25;4(196):ra70.

Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN. MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev. 2009 Sep15;23(18): 2166-78.

Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Nakagawa O, Olson EN. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A. 2007.  May 8;104(19):7975-80.

Xin M, Davis CA, Molkentin JD, Lien CL, Duncan SA, Richardson JA, Olson EN. A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci U S A. 2006 Jul25;103(30): 11189-94.